ID   A0A1E7MZI0_KITAU        Unreviewed;       848 AA.
AC   A0A1E7MZI0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Polynucleotide kinase-phosphatase {ECO:0000313|EMBL:OEV33821.1};
GN   ORFNames=HS99_0037625 {ECO:0000313|EMBL:OEV33821.1};
OS   Kitasatospora aureofaciens (Streptomyces aureofaciens).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Kitasatospora.
OX   NCBI_TaxID=1894 {ECO:0000313|EMBL:OEV33821.1, ECO:0000313|Proteomes:UP000037395};
RN   [1] {ECO:0000313|EMBL:OEV33821.1, ECO:0000313|Proteomes:UP000037395}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC
RC   12843 / NCIMB 8234 / A-377 {ECO:0000313|Proteomes:UP000037395};
RA   Zhang J.E., Yang H., Guo J., Deng Z., Luo H., Luo M., Zhao B.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000037395}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC
RC   12843 / NCIMB 8234 / A-377 {ECO:0000313|Proteomes:UP000037395};
RA   Gradnigo J.S., Johnson N., Somerville G.A.;
RT   "Sequencing, assembly and comparative genomics of S. aureofaciens ATCC
RT   10762.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OEV33821.1}.
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DR   EMBL; JPRF03000057; OEV33821.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1E7MZI0; -.
DR   Proteomes; UP000037395; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd07423; MPP_Prp_like; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041780; MPP_PrpE-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR024028; PNKP_bac.
DR   InterPro; IPR032380; PNKP_ligase_dom.
DR   NCBIfam; TIGR04075; bacter_Pnkp; 1.
DR   PANTHER; PTHR42850:SF7; BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE PRPE [ASYMMETRICAL]; 1.
DR   PANTHER; PTHR42850; METALLOPHOSPHOESTERASE; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF16542; PNKP_ligase; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Kinase {ECO:0000313|EMBL:OEV33821.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037395};
KW   Transferase {ECO:0000313|EMBL:OEV33821.1}.
FT   DOMAIN          169..365
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          453..843
FT                   /note="Polynucleotide kinase-phosphatase ligase"
FT                   /evidence="ECO:0000259|Pfam:PF16542"
SQ   SEQUENCE   848 AA;  92617 MW;  A079C80AB89420C1 CRC64;
     MIGTSGAGKS TFARRHFLPT QVISSDFCRG LVADDENDQS ASAEAFDVLH YVVGKRLAAG
     RLTVVDATNV QPEARRQLVA LAREHDVLPI AIVLDVPPGV CAERNRSRPD RQLPAHVVPR
     QHRELRRSLR GLEREGFRKV HVLRGEAEVA AAEIELERRY NDLRHLTGPF DVVGDVHGCR
     SELETLLVRL GYTLTRDAEG RPVDAVHPAG RTAVFVGDLV DRGPDTPGVL RLVMGMVAAG
     HALCVPGNHE NKLGRAMDGK KVTVAYGLQE SLDQLAGESE EFRAEVRAFM RGLVSHYLLD
     GGALVVCHAG LPERFHGRAS GRVRSHALYG ETTGETDEYG LPVRYPWAEE YRGRALVVYG
     HTPVPSASFL NNTICLDTGC VFGGSLTALR YPERELVSVE AEQEWYAPVR PLHTDAPGAR
     EGRPLDLADV AGRRIVETGL HGRVAVREEN ATAALEVMSR FALDPRLLAY LPPTMAPSPT
     SRREGYLEHP EEAFAAYRED GVRHLVCEEK HMGSRAVLLV ARDGAALERR FGVAGPGAIW
     TRTGRAFLDD EELTAAVLGR VRSAAERAGL FEELGTDWLL LDAELMPWSL KAVELLRRQY
     AAVGAAAGAA LPAVLSALEQ AAARGLELGE LTSRQRRRAA DARAFTEAYR RYCWPTEGLS
     GIRLAPFQLL AAEGVNLAAR PHDEHLARID RLVEADEALA AEGGDAEQPV LHRTGRVVVD
     TGDEASVSAA TAWWEELTAA GGEGMVVKPL ASVVRTARGE GRPGGLVQPG VKVRGREYLR
     IVYGPDYTEH LDRLRMRSLG HKRSLALREY ALGLEALDRL AAGEPLWRVH EPVFAVLALE
     SEPVDPRL
//