ID A0A1E7NF46_KITAU Unreviewed; 1151 AA.
AC A0A1E7NF46;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=HS99_0001050 {ECO:0000313|EMBL:OEV39331.1};
OS Kitasatospora aureofaciens (Streptomyces aureofaciens).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=1894 {ECO:0000313|EMBL:OEV39331.1, ECO:0000313|Proteomes:UP000037395};
RN [1] {ECO:0000313|EMBL:OEV39331.1, ECO:0000313|Proteomes:UP000037395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC
RC 12843 / NCIMB 8234 / A-377 {ECO:0000313|Proteomes:UP000037395};
RA Zhang J.E., Yang H., Guo J., Deng Z., Luo H., Luo M., Zhao B.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000037395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10762 / DSM 40127 / CCM 3239 / JCM 4008 / LMG 5968 / NBRC
RC 12843 / NCIMB 8234 / A-377 {ECO:0000313|Proteomes:UP000037395};
RA Gradnigo J.S., Johnson N., Somerville G.A.;
RT "Sequencing, assembly and comparative genomics of S. aureofaciens ATCC
RT 10762.";
RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEV39331.1}.
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DR EMBL; JPRF03000001; OEV39331.1; -; Genomic_DNA.
DR RefSeq; WP_050367010.1; NZ_JPRF03000001.1.
DR AlphaFoldDB; A0A1E7NF46; -.
DR Proteomes; UP000037395; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 4.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 3.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 4.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 4.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS50885; HAMP; 4.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OEV39331.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000037395};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 28..74
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 114..166
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 206..258
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 298..350
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 601..832
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1032..1149
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 522..591
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1082
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1151 AA; 122418 MW; 131621EC150278AC CRC64;
MAGPTTSNGS QHRPAIGPDA ALGNEPELRQ LLAGLTAVRD GDFSTKLPDD AHGLLGEIAS
VFNGMVDQLS HFTSEVTRVA REVGTEGRLG GQAQVPGVSG TWADLTDSVN AMAGNLTWQV
RGIAQVTTAV ARGDLTQKIE VDARGEILEL KNTVNTMVDQ LSSFAGEVTR VAREVGTEGI
LGGQARVVGV SGTWRDLTDS VNSMAGNLTG QVRAIAQVAT AVAEGDLSQK ITVTARGEIL
ELKETINTMV DQLSSFADEV TRVAREVGTE GRLGGQAKVE GVSGTWKRLT ENVNELAGNL
TRQVRAIAEV TSAVAAGDLT RSITVDASGE VADLKDNVNF MVESLRETTR ANEEQDWLKT
NLARFSALMQ GRRDLGVVAE SVMDELAPLV EAQCGAFYLA EDSPEGTVLQ LVGSYAFPDG
ERPTRFRLGE SFVGQAARSR RTIAVDALPA GYLPASSGLG RTDSLSLLVL PIVVEDQVLG
VIELASVQPF TQVHRDFLNQ LMETIGVNVN TIIANARTDE LLGESQRLAA ELQARSEELQ
ARQEELQFSN AELEDKAELL AAQNRDIETK NLEIEQARQE LEERAHQLSL ASKYKSEFLA
NMSHELRTPL NSLLILAQLL AQNPTRNLTA KQVEYAGIIH SAGSDLLQLI NDILDLSKVE
AGKMDLNVDA VPLHALLDYV EATFRPLTGQ KNLAFAVRTA PGVPGELLTD DYRLRQVLRN
LLSNAVKFTE HGRVELRIEP ATDAELPDGV RRGGPVLAFR VTDTGIGIAP QHLETVFGAF
QQADGTTSRK YGGTGLGLSI SREIAFLLGG AITVESTLGR GTVFTLYLPV EHSVVAGSEL
PPAAGAPAGA AAGPAPEQPV DPADHPTTER PRRLLVVEGR PNGLLTLVAE NAVADLARYS
AGHRQVEIVT AVGAQDAATA LATAPCHCVV LELDLPDGTA GALLADMEGD PALHTVPVLA
HNNRGVTGER AGSVSRPGER PLELIASLDE LRGRIALHMS ADRPGGALPP GRGADLVPSW
SPDAEPALAG RTALVVDDDD RNLYAITSIL ELHGMRVLQA ENGRAALESL TVHPGIDVIL
MDVMMPEMDG YTATAAIRAM PEHAGLPIIA VTAKAMIGDR EKSLAAGASD YITKPVDADE
VISRITHHLT R
//
