ID A0A1E7R5U9_9GAMM Unreviewed; 372 AA.
AC A0A1E7R5U9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=BJI46_13380 {ECO:0000313|EMBL:OEY94633.1}, F4V57_02055
GN {ECO:0000313|EMBL:KAA8735600.1};
OS Acinetobacter qingfengensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter.
OX NCBI_TaxID=1262585 {ECO:0000313|EMBL:OEY94633.1, ECO:0000313|Proteomes:UP000185895};
RN [1] {ECO:0000313|EMBL:OEY94633.1, ECO:0000313|Proteomes:UP000185895}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ANC 4671 {ECO:0000313|EMBL:OEY94633.1,
RC ECO:0000313|Proteomes:UP000185895};
RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAA8735600.1, ECO:0000313|Proteomes:UP000323633}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 69710T {ECO:0000313|EMBL:KAA8735600.1,
RC ECO:0000313|Proteomes:UP000323633};
RA Pineiro-Iglesias B., Tunovic T., Unosson C., Inganas E., Ohlen M.,
RA Cardew S., Jensie-Markopoulos S., Salva-Serra F., Jaen-Luchoro D.,
RA Karlsson R., Svensson-Stadler L., Chun J., Moore E.;
RT "Draft genome sequence of various Type strains from the CCUG.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEY94633.1}.
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DR EMBL; VXKN01000001; KAA8735600.1; -; Genomic_DNA.
DR EMBL; MKKK01000031; OEY94633.1; -; Genomic_DNA.
DR RefSeq; WP_070070125.1; NZ_VXKN01000001.1.
DR AlphaFoldDB; A0A1E7R5U9; -.
DR STRING; 1262585.BJI46_13380; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000185895; Unassembled WGS sequence.
DR Proteomes; UP000323633; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:KAA8735600.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185895}.
FT DOMAIN 23..345
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 372 AA; 42139 MW; 4AD31229C8B8938E CRC64;
MSNDYIKHPD VLVESLKNGW WSVRLNRPKS LHALDEQIVT ALYSTFEYLH QNDLVKAIWF
DSTTPKAFCA GGDVRKLRQL VLEDQLEQAK QFFKQEYALD RLLHHYAKPL VVWGEGYVMG
GGLGLFMAAP FRLVTPHSRL AMPEINIGLY PDVGATRFLA DRGTIGLFIG LTGSIMTAAG
AYSIGWATHV CEQGRDIVLN HLTSIRWKDY SAGDFRAIDD TLNSLHRPLA AGPLQNSLDV
IHSVCRGQDF IQDYQSICGL GNARSDWLRQ ASENLSNGSP TTAALTWLLW QWAKQNRSWN
EVFSLEEEIS GWKIQHADFI EGVRARLVDK DLQPDWQKKS FQNLADLFKD NPPFSESVDS
WNALLRQYGI LK
//
