ID A0A1E7RM65_9GAMM Unreviewed; 480 AA.
AC A0A1E7RM65;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA-binding transcriptional regulator NtrC {ECO:0000256|ARBA:ARBA00019059, ECO:0000256|RuleBase:RU365013};
DE AltName: Full=Nitrogen regulation protein NR(I) {ECO:0000256|RuleBase:RU365013};
GN Name=ntrC {ECO:0000256|RuleBase:RU365013};
GN ORFNames=BIY45_11875 {ECO:0000313|EMBL:OEZ00364.1};
OS Stenotrophomonas sp. BIIR7.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Stenotrophomonas.
OX NCBI_TaxID=1904462 {ECO:0000313|EMBL:OEZ00364.1, ECO:0000313|Proteomes:UP000175905};
RN [1] {ECO:0000313|EMBL:OEZ00364.1, ECO:0000313|Proteomes:UP000175905}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIIR7 {ECO:0000313|EMBL:OEZ00364.1,
RC ECO:0000313|Proteomes:UP000175905};
RA Sanchez-Castro I., Ruiz-Fresneda M.A., Bakkali M., Kampfer P., Busse H.J.,
RA Lopez-Fernandez M., Martinez-Rodriguez P., Merroun M.L.;
RT "Stenotrophomonas bentonitica sp. nov., isolated from bentonite
RT formations.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Member of the two-component regulatory system NtrB/NtrC,
CC which controls expression of the nitrogen-regulated (ntr) genes in
CC response to nitrogen limitation. Phosphorylated NtrC binds directly to
CC DNA and stimulates the formation of open promoter-sigma54-RNA
CC polymerase complexes. {ECO:0000256|RuleBase:RU365013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU365013}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OEZ00364.1}.
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DR EMBL; MKCZ01000051; OEZ00364.1; -; Genomic_DNA.
DR RefSeq; WP_070208274.1; NZ_MKCZ01000051.1.
DR AlphaFoldDB; A0A1E7RM65; -.
DR STRING; 1904462.BIY45_11875; -.
DR GeneID; 84662562; -.
DR OrthoDB; 9804019at2; -.
DR Proteomes; UP000175905; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006808; P:regulation of nitrogen utilization; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR InterPro; IPR010114; Transcript_reg_NtrC.
DR NCBIfam; TIGR01818; ntrC; 1.
DR PANTHER; PTHR32071:SF15; DNA-BINDING TRANSCRIPTIONAL REGULATOR NTRC; 1.
DR PANTHER; PTHR32071; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF02954; HTH_8; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR PRINTS; PR01590; HTHFIS.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|RuleBase:RU365013};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365013};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365013};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365013};
KW Nitrogen fixation {ECO:0000256|RuleBase:RU365013};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365013};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000175905};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU365013};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU365013};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU365013};
KW Two-component regulatory system {ECO:0000256|RuleBase:RU365013}.
FT DOMAIN 9..124
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 149..378
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
FT MOD_RES 59
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 480 AA; 51885 MW; 3D65B40F6FAF3B4A CRC64;
MAADSQAQRV WVVDDDRAVR FVLSTALRDA GYAVEGFDGA AAALDMLASQ PPPDLLFTDV
RMPGDDGLVL LDKLKAAHPQ LPVIVMSAYT DVASTAGAFR GGAQEFLSKP FDLDDAVALA
QRVLPAPDIA VAERSAPTVE ATPDQRPQLV GDTPAMRALF RAIGRLAQAP LSVLINGETG
TGKELVAHAL HHESPRVQGP FVALNTAAIP SELLESELFG HEAGAFTGAQ RRHVGRFEQA
NGGTLFLDEI GDMPLPLQTR LLRVLAEGEF FRVGGRELIR VDVRVIAATH QDLESLVAQG
RFRADLLHRL DVVRLRLPPL RERREDIVQL ADTFLAAAAH KLDTPPKRLT AAALQALREH
DWPGNVRELE NVCWRMAALA ASDTIGVADV DSALHRGPGQ RSRAHGDPGQ WEALLSAWAR
QRLAEGAEGL HAQVRERVDQ ALLEAALQIT HGRRAEAAAR LGMGRNTLTR KLGAGRRRGS
//
