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Database: UniProt
Entry: A0A1E7UBF0_9GAMM
LinkDB: A0A1E7UBF0_9GAMM
Original site: A0A1E7UBF0_9GAMM 
ID   A0A1E7UBF0_9GAMM        Unreviewed;       491 AA.
AC   A0A1E7UBF0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01081161};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AS144_02250 {ECO:0000313|EMBL:OEZ33395.1};
OS   Francisella endosymbiont of Amblyomma maculatum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Francisellaceae.
OX   NCBI_TaxID=255919 {ECO:0000313|EMBL:OEZ33395.1};
RN   [1] {ECO:0000313|EMBL:OEZ33395.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FLE-Am {ECO:0000313|EMBL:OEZ33395.1};
RX   PubMed=27645766; DOI=10.1038/srep33670;
RA   Gerhart J.G., Moses A.S., Raghavan R.;
RT   "A Francisella-like endosymbiont in the Gulf Coast tick evolved from a
RT   mammalian pathogen.";
RL   Sci. Rep. 6:33670-33670(2016).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756121}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS01082709}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OEZ33395.1}.
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DR   EMBL; LNCT01000002; OEZ33395.1; -; Genomic_DNA.
DR   EnsemblBacteria; OEZ33395; OEZ33395; AS144_02250.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   Gene3D; 3.30.300.180; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR038454; DnaA_N_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756129};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS01082702};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00756116};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS01082706};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756117}.
FT   DOMAIN      188    314       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      399    468       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     196    203       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   491 AA;  55767 MW;  B9B8AA3AACFB5FB1 CRC64;
     MTTWDKCLKK IKKNLSTFEY KTWIKPIHVK QNSNLFTIYC NNEYFKKHIK SKYGNLILAT
     IQECYGNDLI IEYSNKKFCG EKITEVITAG PQAIFFSTSS VEIKDESEEA KVVQESKTSK
     KSSTKNFSSS QELFGFDEAM LITAKEDEEY SFGLPLKEKY VFDSFVVGDA NKIARAAAMQ
     VSINPGKLHN PLFIYGGSGL GKTHLIQAIG NHAKEVNPNA KIIYTNSEQF IKDYVNSIRL
     QDQDEFQRVY RSADILLIDD IQFIAGKEGT AQEFFHTFNA LYENGKQIIL TSDKYPNEIE
     GLEERLVSRF GYGLTVSVDM PDLETRIAIL LKKAHDLGQK LPNETAAFIA ENVRTNVREL
     EGALNRVLTT SKFNHKNPTI EVAQSCLRDV IKIQEKKVKI DNIQKVVADF YRIRVKDLIS
     NQRSRNIARP RQIAMSLARE LTSHSLPEIG NAFGGRDHTT VMHAVKAITK LRQSNTSISD
     DYELLLDKIS R
//
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