ID A0A1E8CYU0_9MICO Unreviewed; 407 AA.
AC A0A1E8CYU0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Peptidase M50 {ECO:0000313|EMBL:OFE17574.1};
GN ORFNames=BA895_15095 {ECO:0000313|EMBL:OFE17574.1};
OS Humibacillus sp. DSM 29435.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Humibacillus.
OX NCBI_TaxID=1869167 {ECO:0000313|EMBL:OFE17574.1, ECO:0000313|Proteomes:UP000175826};
RN [1] {ECO:0000313|Proteomes:UP000175826}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 29435 {ECO:0000313|Proteomes:UP000175826};
RA Florea S., Webb J.S., Jaromczyk J., Schardl C.L.;
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFE17574.1}.
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DR EMBL; MAST01000006; OFE17574.1; -; Genomic_DNA.
DR RefSeq; WP_070190903.1; NZ_MAST01000006.1.
DR AlphaFoldDB; A0A1E8CYU0; -.
DR STRING; 1869167.BA895_15095; -.
DR OrthoDB; 9781963at2; -.
DR Proteomes; UP000175826; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR39188; MEMBRANE-ASSOCIATED ZINC METALLOPROTEASE M50B; 1.
DR PANTHER; PTHR39188:SF3; ZINC METALLOPROTEASE SLR1821-RELATED; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000175826};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..192
FT /note="Peptidase M50"
FT /evidence="ECO:0000259|Pfam:PF02163"
SQ SEQUENCE 407 AA; 41838 MW; 1DD654A36692DCCB CRC64;
MSEGGHADRA DQAGRAGNGY GWRIGAVGGT PVYIARSWPL IIVLLLLVVS PTLRSSGRSM
GFAVFVAASS GVLLLVSVLV HEAAHAVVAG LRGHQVDRVV ADVWGGHTVY DSTDVTPGTT
ALVAVVGPLS NLALALVAWL AQPLVSNDLA ANLLGATAYV NLFVGLFNLL PGLPLDGGQI
VSSLVWQVTG RKGTGLSAAG WLGRVVAVGA VLWFIGVPLL RGQQPSLISL VWVAMIAFFL
WRGASASIRS GQIHDATAGP ALSVLEPVVL VAGDMTVAAA ANLMVGAPSF STETEGGPAA
APRGAWVAVT DSGGWPFGLV DPAAAAAVPV VSRHTARLSA VALAQPRAWV LELPPDAVLT
ELVRLMSERS LSVAIVVDAQ TRRVAGLATA QHINDVVGAE LARRGRR
//
