ID A0A1E8F115_9CLOT Unreviewed; 563 AA.
AC A0A1E8F115;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=pcrA_1 {ECO:0000313|EMBL:OFI07128.1};
GN ORFNames=CLOACE_05330 {ECO:0000313|EMBL:OFI07128.1};
OS Clostridium acetireducens DSM 10703.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1121290 {ECO:0000313|EMBL:OFI07128.1, ECO:0000313|Proteomes:UP000175744};
RN [1] {ECO:0000313|EMBL:OFI07128.1, ECO:0000313|Proteomes:UP000175744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10703 {ECO:0000313|EMBL:OFI07128.1,
RC ECO:0000313|Proteomes:UP000175744};
RA Poehlein A., Fluechter S., Duerre P., Daniel R.;
RT "Genome sequence of Clostridium acetireducens DSM 10703.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFI07128.1}.
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DR EMBL; LZFO01000005; OFI07128.1; -; Genomic_DNA.
DR RefSeq; WP_070109496.1; NZ_LZFO01000005.1.
DR AlphaFoldDB; A0A1E8F115; -.
DR STRING; 1121290.CLAOCE_05330; -.
DR PATRIC; fig|1121290.3.peg.541; -.
DR OrthoDB; 9787585at2; -.
DR Proteomes; UP000175744; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000175744}.
FT DOMAIN 30..334
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 51..58
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 563 AA; 66984 MW; CA404BA4E7FEDF80 CRC64;
MAIDNESLEF FVKLSKVWGN FNEYNFFKEI ELSPEQIKVV EYEDEQMLIE GCAGTGKSIT
LLYKFIKTLI NENNKKILYV TFNNILIEDT KKRLETCNEF NDNKKKHDIR ICTFHDIACE
ILKSIKVIDK KLGKLTANKI ENHRETAFRR IAAILANYKD DFSLIYKNLF KEERLYKTHD
ASFIRDEIFW MKANGIVNKN DYLSVKRSGR SQSIRLTVAQ RNTVFKIFEE YQSQLKDKFH
NHLDLEDYAL EIIKNYYMNR LEDNKFDYIF VDELQDLDPM QLKALCLLTK KSIVVSGDSR
QKIYKKSPLT YERIGFKIHE KGRHKILNKN YRSTAQIIKL ANELNFSDND TAKYKEKNFI
KQGKKPIIAL FQSEKGAINY VSKMINEIFE KDTKKTIAIV HREDLKPKYK YKKSIRRILL
EQKILTGFSD IYNYSKRFEH IGNKQIFYTN PYDVKGLEFD IVFILDFNYK YYPNYLEIKE
INENLEGKDK DLIDKDIEQV INMEKRLFYV AMTRAKSELY IIANGCKRIA QISKFILDFN
SDNYINKNFL KKDIEKMKFL RDI
//
