ID A0A1E8FES1_9ALTE Unreviewed; 531 AA.
AC A0A1E8FES1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Homocitrate synthase {ECO:0000256|ARBA:ARBA00020735};
DE EC=2.3.3.14 {ECO:0000256|ARBA:ARBA00012974};
GN ORFNames=BFC17_17575 {ECO:0000313|EMBL:OFI34447.1};
OS Alteromonas lipolytica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Alteromonas/Salinimonas group; Alteromonas.
OX NCBI_TaxID=1856405 {ECO:0000313|EMBL:OFI34447.1, ECO:0000313|Proteomes:UP000176037};
RN [1] {ECO:0000313|EMBL:OFI34447.1, ECO:0000313|Proteomes:UP000176037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JW12 {ECO:0000313|EMBL:OFI34447.1,
RC ECO:0000313|Proteomes:UP000176037};
RA Wu Y.-H., Cheng H., Xu X.-W.;
RT "Alteromonas lipolytica, a new species isolated from sea water.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is a Fe-Mo-cofactor biosynthetic component.
CC {ECO:0000256|ARBA:ARBA00003050}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA +
CC H(+); Xref=Rhea:RHEA:12929, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16810, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:58884; EC=2.3.3.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000596};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFI34447.1}.
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DR EMBL; MJIC01000011; OFI34447.1; -; Genomic_DNA.
DR RefSeq; WP_070176320.1; NZ_MJIC01000011.1.
DR AlphaFoldDB; A0A1E8FES1; -.
DR STRING; 1856405.BFC17_17575; -.
DR OrthoDB; 9803573at2; -.
DR Proteomes; UP000176037; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd07944; DRE_TIM_HOA_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR000891; PYR_CT.
DR PANTHER; PTHR42880; HOMOCITRATE SYNTHASE; 1.
DR PANTHER; PTHR42880:SF1; ISOPROPYLMALATE_HOMOCITRATE_CITRAMALATE SYNTHASE FAMILY PROTEIN; 1.
DR Pfam; PF00682; HMGL-like; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
DR PROSITE; PS50991; PYR_CT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000176037};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..257
FT /note="Pyruvate carboxyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50991"
SQ SEQUENCE 531 AA; 57849 MW; D6205451FF4D9E83 CRC64;
MLILDCTLRD GGYYNSWNFP ANVVADYLNA MSAAKVDIVE LGLRSLKNSE FKGASAYTTD
EYISSLNVPE SLDVAVMVNA SELVGKTPLD ETLSILFPND SNSSPVKVVR IACHVHEFES
ALPAATLLKD KGFKVGFNLM QVADRSQHEV ENLAKAASEY DIDALYFADS MGSMDPAQCK
TIITWLQKYW DGAIGIHTHD NMGKALQNTL TAIDAGVTWL DATVTGMGRG PGNARTEELA
IEVSSLKGEQ VNLVPLLSLI KSYFQPLKNE CGWGSNPYYY LSGKYGIHPT FVQEMLSDPR
FDEEDILATL EHLRIEGGSK FSHDTLDATR NFYANPPKGS WEPKTALSGK DVLILGAGQG
LTEHSAAVQS YIDKYKPVVI AMNTQSVLTE DKIDLRIASH PVRLLADCEK HAKLPQPLIV
PRDALPADVL ESLGDKHCLN FGLQVSGNEF IVNPADAVLP NSLVISYALA VAASGNCNQI
YLAGFDGFGA SDNRTQEMQK VFNLFTEKTG LSLISITNST YDIPSLSVYG L
//
