ID A0A1E8GN98_9LACT Unreviewed; 580 AA.
AC A0A1E8GN98;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN ORFNames=BG261_04820 {ECO:0000313|EMBL:OFI48988.1};
OS Floricoccus tropicus.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Floricoccus.
OX NCBI_TaxID=1859473 {ECO:0000313|EMBL:OFI48988.1, ECO:0000313|Proteomes:UP000178622};
RN [1] {ECO:0000313|Proteomes:UP000178622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DF1 {ECO:0000313|Proteomes:UP000178622};
RA Chuah L.-O., Yap K.-P., Thong K.L., Liong M.T., Ahmad R., Rusul G.;
RT "Draft genome sequence of a novel species of the family Streptococcaceae
RT isolated from flowers.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFI48988.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MKIR01000022; OFI48988.1; -; Genomic_DNA.
DR RefSeq; WP_070792614.1; NZ_MKIR01000022.1.
DR AlphaFoldDB; A0A1E8GN98; -.
DR STRING; 1859473.BG261_04820; -.
DR OrthoDB; 1654473at2; -.
DR Proteomes; UP000178622; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Reference proteome {ECO:0000313|Proteomes:UP000178622};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 27..580
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 354..381
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 580 AA; 66566 MW; 3AC23983128A83CC CRC64;
MPTTVIWVLV TIAVVAIAAY ILIMIMRKGN ENRIHKLEEE KEKLLDLPVQ DEIDAVKKMH
LVGQSQNIYR EWNQKWIDLS SNSFADLEKH LFDAEELNSH FHFLNARTEI DACEKQLDLM
KGDAENIRGA ISELAAQEQR NSTKIQESLD LYEGLRNEIS ENAEAYGTTI GEIEKQLNNI
EEEFTNFVTL NSTGDPIEAA EVLENAEEHT IALGNITKRI PEIVKVVEEE FPRKISELNE
GYAKFEELEY KLPATLDFKQ EINNIQDRMK SSTEFAERFE LDRAESEIKL INDDINELYD
IFESEYAASR LVEQNAGSIK SYIDHTRENN KNLLLEIDHV SQSYVLTGNE MGQVRAYQAQ
IEQATNDTDE LLEDIAENTE ANSVFSSRLK AIQGLLEEIE DNQLKINDSL SKLKVSEKDA
QVKADAFDIE LRTIKRYVEK LNLPGLPKEY LDLFYMATSR VESLFKELNK VRVNVDTLNH
LLDISNEDMN VLEDATDKLT DDANLAEQLI QYSNRYKTTD GEVAKAFNRA VQVFDNEWDY
GKAREDISTA LEQAEPGAVD RISNFYFNNK EVPDYKGIRR
//
