ID A0A1F1E5M9_9PORP Unreviewed; 614 AA.
AC A0A1F1E5M9;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Cobalt-precorrin-5B C(1)-methyltransferase {ECO:0000256|HAMAP-Rule:MF_00787};
DE EC=2.1.1.195 {ECO:0000256|HAMAP-Rule:MF_00787};
DE AltName: Full=Cobalt-precorrin-6A synthase {ECO:0000256|HAMAP-Rule:MF_00787};
GN Name=cbiD {ECO:0000256|HAMAP-Rule:MF_00787};
GN ORFNames=HMPREF2890_03305 {ECO:0000313|EMBL:OFR37764.1};
OS Porphyromonas sp. HMSC065F10.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=1739394 {ECO:0000313|EMBL:OFR37764.1, ECO:0000313|Proteomes:UP000177035};
RN [1] {ECO:0000313|EMBL:OFR37764.1, ECO:0000313|Proteomes:UP000177035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMSC065F10 {ECO:0000313|EMBL:OFR37764.1,
RC ECO:0000313|Proteomes:UP000177035};
RA Wen L., He K., Yang H.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to
CC form cobalt-precorrin-6A. {ECO:0000256|HAMAP-Rule:MF_00787}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A +
CC S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:26285, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:60063, ChEBI:CHEBI:60064;
CC EC=2.1.1.195; Evidence={ECO:0000256|HAMAP-Rule:MF_00787};
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route):
CC step 6/10. {ECO:0000256|HAMAP-Rule:MF_00787}.
CC -!- SIMILARITY: Belongs to the CbiD family. {ECO:0000256|HAMAP-
CC Rule:MF_00787}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFR37764.1}.
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DR EMBL; LTXH01000107; OFR37764.1; -; Genomic_DNA.
DR RefSeq; WP_070465306.1; NZ_KV793774.1.
DR AlphaFoldDB; A0A1F1E5M9; -.
DR STRING; 1739394.HMPREF2890_03305; -.
DR OrthoDB; 6439987at2; -.
DR UniPathway; UPA00148; UER00227.
DR Proteomes; UP000177035; Unassembled WGS sequence.
DR GO; GO:0043780; F:cobalt-precorrin-5B C1-methyltransferase activity; IEA:RHEA.
DR GO; GO:0016994; F:precorrin-6A reductase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0046140; P:corrin biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2110.10; CbiD-like; 1.
DR HAMAP; MF_00787; CbiD; 1.
DR InterPro; IPR002748; CbiD.
DR InterPro; IPR036074; CbiD_sf.
DR InterPro; IPR003723; Precorrin-6x_reduct.
DR NCBIfam; TIGR00312; cbiD; 1.
DR PANTHER; PTHR35863; COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR35863:SF1; COBALT-PRECORRIN-5B C(1)-METHYLTRANSFERASE; 1.
DR Pfam; PF01888; CbiD; 1.
DR Pfam; PF02571; CbiJ; 1.
DR SUPFAM; SSF111342; CbiD-like; 1.
DR PROSITE; PS51014; COBK_CBIJ; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW Rule:MF_00787};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW Rule:MF_00787}; Reference proteome {ECO:0000313|Proteomes:UP000177035};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW Rule:MF_00787};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00787}.
SQ SEQUENCE 614 AA; 67188 MW; B3E3B03101E50143 CRC64;
MGKILIIGGT TEGRAAVEVC EEAGKPFLYS TLGTSQEIAL HHGTRLEGPL DADAMTSLCR
REEVSVLVDA AHPFATIVHR NVAKAASEVA LPTVRYERAF PPLPEGALSV SSFPEAMKEL
ERLAPRRLLA LTGVKSIAAM GDYPLRHEVW LRVMPIPETE RIISESDFPR NRLIYYDREQ
DDRALMERLR PDLLLLKESG ESSGFEEKVK AATALGIPIL VIRRPTLGYR PTETVLGPVG
LRRALERLDP DFFPLRIGFT TGTTATAATT AALLALLNDE TYAEVPVRLL TGEEIRFPIS
ETCIESEECA TATAIKYSGD DPDVTSGTTI LSTVRLTDSH TGVTFYGGKG VGRITLPGIG
LPIGDPAINP GPRQMMTEAV GRLVDLSRVG IDITITVPEG ETLAPHTFNP RLGVVDGISI
LGTTGVLRPF STEAWVDSIR REMGVSRSVF GEHLVINSGG KSERWLRAHF PDLPPNAFVQ
YGNFIGRCLE MARSMDFAHI TLGIMIGKAV KLAEGQLDTH SKKSVMSKPF IRSLGRESGL
DEATLDRIDG ITMAGEIWEI LPDHAHPFYH ILLDRCYAVC KPLVPGIRLD LILIDKEGGL
IERNAEDKNK RNHV
//
