ID A0A1F1UU69_9CORY Unreviewed; 499 AA.
AC A0A1F1UU69;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN ORFNames=HMPREF3170_06575 {ECO:0000313|EMBL:OFT29626.1};
OS Corynebacterium sp. HMSC08D02.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1581138 {ECO:0000313|EMBL:OFT29626.1, ECO:0000313|Proteomes:UP000177600};
RN [1] {ECO:0000313|EMBL:OFT29626.1, ECO:0000313|Proteomes:UP000177600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HMSC08D02 {ECO:0000313|EMBL:OFT29626.1,
RC ECO:0000313|Proteomes:UP000177600};
RA Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA Babar A., Rosenke K.;
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate + L-glutamine = anthranilate + H(+) + L-glutamate +
CC pyruvate; Xref=Rhea:RHEA:21732, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16567, ChEBI:CHEBI:29748, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359; EC=4.1.3.27;
CC Evidence={ECO:0000256|ARBA:ARBA00000329};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the anthranilate synthase component I family.
CC {ECO:0000256|ARBA:ARBA00009562}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFT29626.1}.
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DR EMBL; LWNU01000033; OFT29626.1; -; Genomic_DNA.
DR RefSeq; WP_070478626.1; NZ_KV789249.1.
DR AlphaFoldDB; A0A1F1UU69; -.
DR OrthoDB; 3518032at2; -.
DR Proteomes; UP000177600; Unassembled WGS sequence.
DR GO; GO:0004049; F:anthranilate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR005257; Anth_synth_I_TrpE.
DR InterPro; IPR015890; Chorismate_C.
DR NCBIfam; TIGR00565; trpE_proteo; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF49; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR PRINTS; PR00095; ANTSNTHASEI.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000177600}.
FT DOMAIN 16..176
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 215..479
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
SQ SEQUENCE 499 AA; 53973 MW; C6EA715830CC023F CRC64;
MSTHNTRRVK YHADAASLFA HLGGTTTRDT VLLESADITT RSGIQSVAVL RAAVRVTCSG
SHVHVEPLTP FGRTVADQLR EQLGEYHVGE NVYAFPPVAA AVVADERERL TATSTVEVLR
ALSRFGFLAG GFAYDYLETF EELPAVADGA NTYPDYQFVL AEVLLRIDHQ SQTATLSGVG
IDALAERIDA ASPTPLRSSE EAGGTLVARA DIPDATFCAD VERLKEHIYN GDIYQVVPAR
SFIADCPDAF AAYLQLRATN PSPYMFYQRG VDKHGDSFEL FGASPESNLK YTNADREVQL
YPIAGTRPRG LAEDGTVDHE LDTRMELQLR TDAKEVAEHT MLVDLARNDV ARVAEPGTRR
VAELLQVDRY SRVMHLVSRV TARLAGDLDA LDAYRACMNM GTLTGAPKLR ATSLIRSLEG
ARRGSYGGAV GYLDSNGDFD TCIVIRSAYV TGGKAIVQAG AGVVRDSNPQ SEADETLHKA
YAVLNAIALA AGAELEVIK
//
