ID   A0A1F1UX61_9CORY        Unreviewed;      1103 AA.
AC   A0A1F1UX61;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HMPREF3170_03725 {ECO:0000313|EMBL:OFT30630.1};
OS   Corynebacterium sp. HMSC08D02.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC   Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=1581138 {ECO:0000313|EMBL:OFT30630.1, ECO:0000313|Proteomes:UP000177600};
RN   [1] {ECO:0000313|EMBL:OFT30630.1, ECO:0000313|Proteomes:UP000177600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HMSC08D02 {ECO:0000313|EMBL:OFT30630.1,
RC   ECO:0000313|Proteomes:UP000177600};
RA   Evans L.H., Alamgir A., Owens N., Weber N.D., Virtaneva K., Barbian K.,
RA   Babar A., Rosenke K.;
RL   Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OFT30630.1}.
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DR   EMBL; LWNU01000010; OFT30630.1; -; Genomic_DNA.
DR   RefSeq; WP_070477914.1; NZ_KV789237.1.
DR   AlphaFoldDB; A0A1F1UX61; -.
DR   Proteomes; UP000177600; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF23; RECBCD ENZYME SUBUNIT RECB; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000177600}.
FT   DOMAIN          4..433
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          465..754
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         25..32
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1103 AA;  121229 MW;  82016EF8FE51ABEB CRC64;
     MTLLPDFENR ERIRTDVDST LFVEAGAGAG KTYSLVQRLL TLILEREVPV TQIAAITFTK
     KAAAELSERL ARELAKHAGN PVADRALLEL PSAAIETLHS FCQRLLCLYP LESGIPPEIT
     VQDNFAEERQ SDVLRRRVSE AFSSALEGVF PIAELSGGKI LDADLREALE HFAGENGSMS
     SLLQLAQYMD DNWGELEPTI AAALPEAFVF DEDAATRIVG ELKRTLNECS DPEDAFALTL
     GEQITDLQLR ITAGDFTKVG KFRKGNGGRK ANWGGAVVKE IKSACERVWD SWNENVERQA
     ARPKAVLRAS LALIVLDNAR RRHRTGELQF GDLVYLADQL LKHHPHVRED VHTRFTHLLV
     DEFQDTDPAQ LRIVRAIATD PATGKLTPGA LFTVGDPKQS IYRFRHADLD TYLAARDAQD
     CEVVELTTNF RSTSKVLDWS NQVFERYFPN ALATSKKPDP KLVPREVAFT ALDARPGLDD
     APELADFNSR TIVAHYEAIK EDNLSKEEAE CRLILSIIKQ ALAEDWQRRD KVVRDDGTSY
     ETLVGLEPHD IAILVRTHRQ AASLMAFLDA HDVPYVPEGA ALTYLAPEIE ELHVVLHAAA
     DPAESLSVGA ALRTSLLGIS DLELAQWAAA GSSLNIYGPR LHDLTGRIPD ALNLILKLHE
     ASREMSVGAL VSWACDQLNM VELAAARSAF PLEALRRLEF VKHNARAFTE ATHGTLREYT
     AWTDSLANER HQITDPESTT AGGVRILTLH ASKGREFPMV ILAGMYGGRN NNPQVSRPHP
     ADHVLEYSEF RLTSPRSREI LEHEKLADAA ERARLFYVAT TRARDHLVVC KRTDNPNSVA
     SKAFNTAIEN TIAEGAIPEA IAAEDIPAYE YDFTTSATRP TEPNAEGLPD LHASESAWQS
     ARARRVASTA VAHARDADVV KLGLTRETAS LDPALVVTGE ARAEHGAAVG TALHAMMERA
     TLDDLTAAGG AADYAATLSV DCGAPSQFRE TLASMAEQLL ECETVTHAFS SQHYRELPVF
     GRLSSGGPII DGVVDLLYRE GDSWVIADYK TDVSADAQTV SEYFNQLRLY AELLGGELDA
     PITRLELLFP RKQGVVIRTR SLG
//