ID A0A1F2P429_9EURY Unreviewed; 534 AA.
AC A0A1F2P429;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=ENI32_06010 {ECO:0000313|EMBL:HEC57417.1}, SBU_000986
GN {ECO:0000313|EMBL:OFV66049.1};
OS Candidatus Syntrophoarchaeum butanivorans.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinales incertae sedis; ANME-2 cluster;
OC Syntrophoarchaeum.
OX NCBI_TaxID=1839936 {ECO:0000313|EMBL:OFV66049.1, ECO:0000313|Proteomes:UP000185779};
RN [1] {ECO:0000313|EMBL:OFV66049.1, ECO:0000313|Proteomes:UP000185779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BOX1 {ECO:0000313|EMBL:OFV66049.1};
RA Laso-Perez R., Richter M., Wegener G., Musat F.;
RT "Microbial consortia oxidize butane by reversing methanogenesis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HEC57417.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HyVt-386 {ECO:0000313|EMBL:HEC57417.1};
RX PubMed=31911466;
RA Zhou Z., Liu Y., Xu W., Pan J., Luo Z.H., Li M.;
RT "Genome- and Community-Level Interaction Insights into Carbon Utilization
RT and Element Cycling Functions of Hydrothermarchaeota in Hydrothermal
RT Sediment.";
RL mSystems 5:e00795-e00719(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFV66049.1}.
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DR EMBL; DRIE01000102; HEC57417.1; -; Genomic_DNA.
DR EMBL; LYOR01000004; OFV66049.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F2P429; -.
DR STRING; 1839936.SBU_000986; -.
DR PATRIC; fig|1839936.3.peg.995; -.
DR Proteomes; UP000185779; Unassembled WGS sequence.
DR Proteomes; UP000885936; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:HEC57417.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185779};
KW Transferase {ECO:0000313|EMBL:HEC57417.1}.
FT DOMAIN 17..159
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 170..494
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 534 AA; 61311 MW; 1609ABF1550E9742 CRC64;
MVSRNARSNG DLNFMDELWE AANRLRGSMD AAEYKNVVLG LIFLKYVSDM FEFRRKWLEN
VVRDKTTEYY VENATDDYIK ELVEDKDEYI QAGVFYIPSN ARWDHLMANA MSPEIGKLID
SAMRGIEKEN AEQLKGVLPK IYTGSRLSPV TLGELINLFS RVGFCQEDRE KDILGRVYEY
FIGQFAQAEG RKGGEFYTPR CVVKLLVDIL EPYEGRVYDP ACGSGGMFVQ SWKFIEAHHK
NPYAISIYGQ EKNGTTWRIC KMNLAIRGIP SENIALGDTL LDDKFPTLKA DFIITNPPFN
MTKWGANRVQ KDARWEFGIP DDTSKNGGNY AWIQHYIYHL SPRGRAGFVM ANGSLSCGGK
YGEIRKRIIE NDLVDCIVAL PPKLFLTTQI PACLWFLARN KDESGIGYRD RRRDILFIDA
REMFDKVSRN LNELSDEHIR KIADTYRAWR GIAEAGEYED VPGFCKAVTL EEIRKHNYIL
TPGSYVGIAE EEEDDEPFEQ KMVRLTKQLA EQFARADELK ERIRKNLGEL GYGF
//
