ID A0A1F2P6N4_9EURY Unreviewed; 218 AA.
AC A0A1F2P6N4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000256|HAMAP-Rule:MF_00135};
DE Short=PRAI {ECO:0000256|HAMAP-Rule:MF_00135};
DE EC=5.3.1.24 {ECO:0000256|HAMAP-Rule:MF_00135};
GN Name=trpF {ECO:0000256|HAMAP-Rule:MF_00135};
GN ORFNames=ENI32_07015 {ECO:0000313|EMBL:HEC57608.1}, SBU_000280
GN {ECO:0000313|EMBL:OFV66987.1};
OS Candidatus Syntrophoarchaeum butanivorans.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinales incertae sedis; ANME-2 cluster;
OC Syntrophoarchaeum.
OX NCBI_TaxID=1839936 {ECO:0000313|EMBL:OFV66987.1, ECO:0000313|Proteomes:UP000185779};
RN [1] {ECO:0000313|EMBL:OFV66987.1, ECO:0000313|Proteomes:UP000185779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BOX1 {ECO:0000313|EMBL:OFV66987.1};
RA Laso-Perez R., Richter M., Wegener G., Musat F.;
RT "Microbial consortia oxidize butane by reversing methanogenesis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HEC57608.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HyVt-386 {ECO:0000313|EMBL:HEC57608.1};
RX PubMed=31911466;
RA Zhou Z., Liu Y., Xu W., Pan J., Luo Z.H., Li M.;
RT "Genome- and Community-Level Interaction Insights into Carbon Utilization
RT and Element Cycling Functions of Hydrothermarchaeota in Hydrothermal
RT Sediment.";
RL mSystems 5:e00795-e00719(2020).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC EC=5.3.1.24; Evidence={ECO:0000256|ARBA:ARBA00001164,
CC ECO:0000256|HAMAP-Rule:MF_00135};
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5. {ECO:0000256|ARBA:ARBA00004664,
CC ECO:0000256|HAMAP-Rule:MF_00135}.
CC -!- SIMILARITY: Belongs to the TrpF family. {ECO:0000256|ARBA:ARBA00007571,
CC ECO:0000256|HAMAP-Rule:MF_00135}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFV66987.1}.
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DR EMBL; DRIE01000113; HEC57608.1; -; Genomic_DNA.
DR EMBL; LYOR01000001; OFV66987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F2P6N4; -.
DR STRING; 1839936.SBU_000280; -.
DR PATRIC; fig|1839936.3.peg.282; -.
DR UniPathway; UPA00035; UER00042.
DR Proteomes; UP000185779; Unassembled WGS sequence.
DR Proteomes; UP000885936; Unassembled WGS sequence.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd00405; PRAI; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR044643; TrpF_fam.
DR PANTHER; PTHR42894; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR PANTHER; PTHR42894:SF1; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00135};
KW Aromatic amino acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00135};
KW Isomerase {ECO:0000256|HAMAP-Rule:MF_00135, ECO:0000313|EMBL:OFV66987.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000185779};
KW Tryptophan biosynthesis {ECO:0000256|HAMAP-Rule:MF_00135}.
FT DOMAIN 4..211
FT /note="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)"
FT /evidence="ECO:0000259|Pfam:PF00697"
SQ SEQUENCE 218 AA; 23673 MW; 1B162923FDEC25DD CRC64;
MTFIKICGIR TEQDLRIVVG AGVDAAGFII EVPVETPRKI SRWTASGLVR SLPGDVLGVA
VLMPASIDEA VEIIDLVEPD MVQIHSDMDP NRLYELKERC DLPLIKVLGI RRGVDRETIL
SEVDHVSGVV DFILLDTKLN QRSGGTGEVH DWSVSREVVR SSPVPVILAG GLNPLNVGDA
IKFVRPYGVD TASGVETGGR KDPDKVRRFV EAVRRSGG
//
