ID A0A1F2P6X9_9EURY Unreviewed; 767 AA.
AC A0A1F2P6X9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=NADH-quinone oxidoreductase subunit B/C/D {ECO:0000256|ARBA:ARBA00015619};
DE AltName: Full=NADH dehydrogenase I subunit B/C/D {ECO:0000256|ARBA:ARBA00030498};
DE AltName: Full=NDH-1 subunit B/C/D {ECO:0000256|ARBA:ARBA00031560};
GN ORFNames=SBU_000216 {ECO:0000313|EMBL:OFV66923.1};
OS Candidatus Syntrophoarchaeum butanivorans.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinales incertae sedis; ANME-2 cluster;
OC Syntrophoarchaeum.
OX NCBI_TaxID=1839936 {ECO:0000313|EMBL:OFV66923.1, ECO:0000313|Proteomes:UP000185779};
RN [1] {ECO:0000313|EMBL:OFV66923.1, ECO:0000313|Proteomes:UP000185779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BOX1 {ECO:0000313|EMBL:OFV66923.1};
RA Laso-Perez R., Richter M., Wegener G., Musat F.;
RT "Microbial consortia oxidize butane by reversing methanogenesis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124;
CC Evidence={ECO:0000256|ARBA:ARBA00000100};
CC -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD,
CC E, F, and G constitute the peripheral sector of the complex.
CC {ECO:0000256|ARBA:ARBA00038617}.
CC -!- SUBUNIT: NDH-1 is composed of about 13 different subunits. Subunits
CC NuoBCD, E, F, and G constitute the peripheral sector of the complex.
CC {ECO:0000256|ARBA:ARBA00025957}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004515}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004515}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004515}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa
CC subunit family. {ECO:0000256|ARBA:ARBA00010019}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the complex I 20 kDa
CC subunit family. {ECO:0000256|ARBA:ARBA00006408}.
CC -!- SIMILARITY: In the central section; belongs to the complex I 30 kDa
CC subunit family. {ECO:0000256|ARBA:ARBA00008265}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFV66923.1}.
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DR EMBL; LYOR01000001; OFV66923.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F2P6X9; -.
DR STRING; 1839936.SBU_000216; -.
DR PATRIC; fig|1839936.3.peg.217; -.
DR Proteomes; UP000185779; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR Gene3D; 3.40.50.12280; -; 1.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR Gene3D; 3.30.460.80; NADH:ubiquinone oxidoreductase, 30kDa subunit; 1.
DR InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR InterPro; IPR037232; NADH_quin_OxRdtase_su_C/D-like.
DR InterPro; IPR006137; NADH_UbQ_OxRdtase-like_20kDa.
DR InterPro; IPR001268; NADH_UbQ_OxRdtase_30kDa_su.
DR InterPro; IPR022885; NDH1_su_D/H.
DR InterPro; IPR029014; NiFe-Hase_large.
DR PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR Pfam; PF00329; Complex1_30kDa; 1.
DR Pfam; PF00346; Complex1_49kDa; 1.
DR Pfam; PF01058; Oxidored_q6; 1.
DR SUPFAM; SSF56770; HydA/Nqo6-like; 1.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR SUPFAM; SSF143243; Nqo5-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Reference proteome {ECO:0000313|Proteomes:UP000185779}.
FT DOMAIN 38..146
FT /note="NADH:ubiquinone oxidoreductase-like 20kDa subunit"
FT /evidence="ECO:0000259|Pfam:PF01058"
FT DOMAIN 230..349
FT /note="NADH:ubiquinone oxidoreductase 30kDa subunit"
FT /evidence="ECO:0000259|Pfam:PF00329"
FT DOMAIN 500..767
FT /note="NADH-quinone oxidoreductase subunit D"
FT /evidence="ECO:0000259|Pfam:PF00346"
SQ SEQUENCE 767 AA; 86975 MW; 69FEBA2BF13850AF CRC64;
MNDEKNRNID ILRTGPFSWL KRWSARWSLW PCHFVTSCCG VELAHASGCG YDMERLGTLT
MGISRQTNTI IVEGTITRKM ARALRIVWEQ MPDPKFVNVI GACGQRGGIF WNSYHITHPH
TIVPVDFFVP GCPVTPEALI RGVRALQKKI EGEDRDTIRF KKANLQFKER KKNMPPTSPK
LLAPTPLIRN DIPGGVGWED GDELVEMVRS RLKGLTASIT VTDERRITIR TREDEIKEIA
KRLSEIGFDH VKSVNLVDVP HEKKLILEYV ISGYSKSLMP ILITLTADIR GKYDLPGLSD
IWQSADYTER ELQDLFGVRF EGNSWNEIFM LAPDTPQSPL RKSFRLEEEE YILKDGVPLT
PHIDPPSDLN APLPSGVLEE VEEMGEYLVL VGPHHTGSGH MRWIMRLDGD IITEIIPDPG
YVHRSMEKIA ESRLYIQNIP LFERLCIVDP VNMNLGYVRA IERALKVDVP ERAAYIRTMM
AELSRIGCFI YDAGIFSLFM GHSTGFMYLW AIREMLLETF LRITGSRCSP SFILPGGVRR
DVGDDLLDLI GNLTTAILPR FKKFEDIFVR NPVLLARVKG VGVLSRDEAV RYGIVGPFLR
ASGVEYDIRK IEPYDAYDSL GWEMITADDG DSLVRFLVRL EEMRESLGIV SQCVDVLKGM
RKGDVISEEI LGDYQEGSRD IRGSLYRVYG NLVLPRGEWT VLTEAARGTL LFSIMSDGES
NVPYRVRVIT PSWMNLRGLI EAARGERMAD FWAIYGSFGY FPPEADR
//
