ID A0A1F2P9Z3_9EURY Unreviewed; 591 AA.
AC A0A1F2P9Z3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Chloride channel protein {ECO:0000313|EMBL:OFV67865.1};
GN ORFNames=SCAL_001240 {ECO:0000313|EMBL:OFV67865.1};
OS Candidatus Syntrophoarchaeum caldarius.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinales incertae sedis; ANME-2 cluster;
OC Syntrophoarchaeum.
OX NCBI_TaxID=1838285 {ECO:0000313|EMBL:OFV67865.1, ECO:0000313|Proteomes:UP000186940};
RN [1] {ECO:0000313|EMBL:OFV67865.1, ECO:0000313|Proteomes:UP000186940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BOX2 {ECO:0000313|EMBL:OFV67865.1};
RA Laso-Perez R., Richter M., Wegener G., Musat F.;
RT "Microbial consortia oxidize butane by reversing methanogenesis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFV67865.1}.
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DR EMBL; LYOS01000003; OFV67865.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F2P9Z3; -.
DR STRING; 1838285.SCAL_001240; -.
DR PATRIC; fig|1838285.3.peg.1260; -.
DR Proteomes; UP000186940; Unassembled WGS sequence.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR CDD; cd00400; Voltage_gated_ClC; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51202; RCK_C; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW Reference proteome {ECO:0000313|Proteomes:UP000186940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 85..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 382..437
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 444..504
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 511..591
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 591 AA; 63322 MW; 1B4EF8EE6C0204C7 CRC64;
MIGSIIVYRF APEAGGEGID TAISAFHQSR GIIPGKVPVV KAIASAITIG SGGSAGREGP
IAQIAGGVGS VLASYLKLSD RDRRIMMVAG ISAGIASIFK SPLGGALFGI EVLYKRDFEM
SAIVPSIMSS VIGYAVFANF TGPGPVFITS ECLFERPIEL VFYGLLGLTC AICGIFYVWF
FYSVRDKFFM RLRIPDYFKP AIGGVGVGVL ILLFPDLISG IIGPGYKALQ DALFGNLAVS
AMIILIFAKI LATSFTVGSG GSGGVFAPSI VIGGMIGGVV GELSHTLFPH IVTNPSCFVL
VGMGSFFGGV AKVPIAAIIM ISEMTGSYAL LAPLMLANAT VYAFTERWTI YESQVSTRMR
SPVHRKELLV DVLESIMVKD AMNPSPLTVS PDDDLKHVYD LMEKTGHMGY PVVKDDKLQG
IVTIKDLEKV PSEEWDEKRV KDVATTALLT VTPDDMLEDA LHWLVMRDIG RLPVVDRDDS
KKLVGILTRS DIARAHVKAM AGDVLTARGK RGVKGLLIHG TRIFEVPIPL HHRLIGKKLA
ELSLPAGIIV AILRSDGVII PTGDTVIEAG DRLVIFSHDD RVDGIKRYLG S
//
