ID A0A1F2PAD0_9EURY Unreviewed; 644 AA.
AC A0A1F2PAD0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=CoB--CoM heterodisulfide reductase iron-sulfur subunit A {ECO:0000256|RuleBase:RU366072};
DE EC=1.8.-.- {ECO:0000256|RuleBase:RU366072};
GN Name=hdrA {ECO:0000313|EMBL:OFV68267.1};
GN ORFNames=SCAL_000907 {ECO:0000313|EMBL:OFV68267.1};
OS Candidatus Syntrophoarchaeum caldarius.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinales incertae sedis; ANME-2 cluster;
OC Syntrophoarchaeum.
OX NCBI_TaxID=1838285 {ECO:0000313|EMBL:OFV68267.1, ECO:0000313|Proteomes:UP000186940};
RN [1] {ECO:0000313|EMBL:OFV68267.1, ECO:0000313|Proteomes:UP000186940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BOX2 {ECO:0000313|EMBL:OFV68267.1};
RA Laso-Perez R., Richter M., Wegener G., Musat F.;
RT "Microbial consortia oxidize butane by reversing methanogenesis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a complex that catalyzes the reversible reduction of
CC CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB
CC (coenzyme B). {ECO:0000256|RuleBase:RU366072}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU366072};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|RuleBase:RU366072};
CC -!- PATHWAY: Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide
CC reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B
CC heterodisulfide: step 1/1. {ECO:0000256|RuleBase:RU366072}.
CC -!- SUBUNIT: The ferredoxin:CoB-CoM heterodisulfide reductase is composed
CC of three subunits; HdrA, HdrB and HdrC.
CC {ECO:0000256|RuleBase:RU366072}.
CC -!- SIMILARITY: Belongs to the HdrA family. {ECO:0000256|ARBA:ARBA00006561,
CC ECO:0000256|RuleBase:RU366072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFV68267.1}.
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DR EMBL; LYOS01000002; OFV68267.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F2PAD0; -.
DR STRING; 1838285.SCAL_000907; -.
DR PATRIC; fig|1838285.3.peg.918; -.
DR UniPathway; UPA00647; UER00700.
DR Proteomes; UP000186940; Unassembled WGS sequence.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.20; -; 2.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR039650; HdrA-like.
DR PANTHER; PTHR43498:SF1; COB--COM HETERODISULFIDE REDUCTASE IRON-SULFUR SUBUNIT A; 1.
DR PANTHER; PTHR43498; FERREDOXIN:COB-COM HETERODISULFIDE REDUCTASE SUBUNIT A; 1.
DR Pfam; PF12831; FAD_oxidored; 1.
DR Pfam; PF00037; Fer4; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 4.
PE 3: Inferred from homology;
KW 4Fe-4S {ECO:0000256|RuleBase:RU366072};
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU366072};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU366072}; Iron {ECO:0000256|RuleBase:RU366072};
KW Iron-sulfur {ECO:0000256|RuleBase:RU366072};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU366072};
KW Oxidoreductase {ECO:0000256|RuleBase:RU366072,
KW ECO:0000313|EMBL:OFV68267.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000186940}.
FT DOMAIN 231..261
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 279..313
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 570..599
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 601..630
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 644 AA; 70505 MW; 0B8CD7FCD175B795 CRC64;
MIGVYVCHCG INIASVVDVK AVAEFARTLP GVTVAKDYQY MCSDPGQELI KNDIKEHGLK
RVVVAACSPR MHEPTFRVAI SDANLNPYLL EVANIREHCS WVHHDREAAT AKAKDLVQSA
VSKAMLLTPL ESREVGVTPR SLVIGGGIAG LEAALDIADA GFKVYLVERE ATLGGHAAQI
ERLFPAMEDA SCLVLPKMAS VMEHPNIEVM TDSEILEVDG YVGNFEVTVV KHPRYVDTTK
CTACGKCEEV CPVDVDDAFN QNLKTRKAIY IPFKSAVPPT YRIDPANCLY FQDGSCKKCV
DVCSDGAINL EEEEVKTKLE VGTIVIATGY EPFDARNKPE FGYGQYDNVI TGLELERMLA
KDGPTGGKVF VKDKEPEKIG FIQCVGSRDK QVGNEYCSRV CCMYTAKQAR MLREMYPDAL
VKVFFMDVRA YGKGYEEFWE ETQRSGVIYV RSNPSEVYRR GDRVVLRGED TLMGEAFEEE
FDLLVLATGL VPRADTRDFG NLLKVSRSGD GFYLEAHPKL RPVDTASDGV YLAGCCQGPK
DITDTISQAN GTAIKACIPL FVGKVSIEPT TSMIDSLICS GCRVCEGICT YGALSFDPEM
GVMTVNEVLC KGCGSCASAC PSSAISMKHF LDQQIFAQIE AIVI
//
