ID A0A1F2S0H6_9BACT Unreviewed; 437 AA.
AC A0A1F2S0H6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
GN ORFNames=A3H28_12200 {ECO:0000313|EMBL:OFV99092.1};
OS Acidobacteria bacterium RIFCSPLOWO2_02_FULL_61_28.
OC Bacteria; Acidobacteriota.
OX NCBI_TaxID=1797180 {ECO:0000313|EMBL:OFV99092.1, ECO:0000313|Proteomes:UP000177212};
RN [1] {ECO:0000313|EMBL:OFV99092.1, ECO:0000313|Proteomes:UP000177212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFV99092.1}.
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DR EMBL; MEKR01000026; OFV99092.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F2S0H6; -.
DR STRING; 1797180.A3H28_12200; -.
DR Proteomes; UP000177212; Unassembled WGS sequence.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:InterPro.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 1.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 248..360
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
SQ SEQUENCE 437 AA; 49005 MW; 941BFA3DCEDDACBD CRC64;
MGKPIPIEEP RGKLGVLLPG MGAVATTFIA GVEAVRRGIG QPIGSLTQMG TIRLGKRTEK
RVPAIREFVP LAALDDLVFG GWDIRSDNCY DIAMQGGVLE PALLGQLRGF LEGIRPWPAV
FDQNYVRRLD GPHVKRGQNK AELAQMLVED IERFRVSTGV SRMVMVWCGS TEIYLQPQEV
HQTLENFECG LKENHPAIAP SMVYSYAALQ SGVPFANGAP NLTVDIPALV ELARQKSVPI
AGKDFKTGQT LMKTIIAPGL KARLIGLSGW FSTNILGNRD GEVLDDPESF RTKEESKLSV
LEHILQPDLY PELYRGFHHL VRINYYPPRG DNKEGWDNID IFGWLGYPMQ IKIDFLCRDS
ILAAPLVLDL VLFLDLAKRA GMRGIQEWLS FYFKSPMCAS TVYPEHDLFI QLMKLKNTLR
YLRGEEMITH LGLEYYD
//
