ID A0A1F3E1Z5_9BACT Unreviewed; 422 AA.
AC A0A1F3E1Z5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Nucleoside permease {ECO:0000313|EMBL:OFX49219.1};
GN ORFNames=A2X13_15325 {ECO:0000313|EMBL:OFX49219.1};
OS Bacteroidetes bacterium GWC2_33_15.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1797324 {ECO:0000313|EMBL:OFX49219.1, ECO:0000313|Proteomes:UP000177978};
RN [1] {ECO:0000313|EMBL:OFX49219.1, ECO:0000313|Proteomes:UP000177978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFX49219.1}.
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DR EMBL; MENN01000029; OFX49219.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F3E1Z5; -.
DR Proteomes; UP000177978; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06177; MFS_NHS; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004740; Nuc_H_symport.
DR NCBIfam; TIGR00889; 2A0110; 1.
DR PANTHER; PTHR23522; BLL5896 PROTEIN; 1.
DR PANTHER; PTHR23522:SF4; NUCLEOSIDE PERMEASE NUPG-RELATED; 1.
DR Pfam; PF03825; Nuc_H_symport; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..422
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 422 AA; 47381 MW; F8940C4F93A9C875 CRC64;
MNIKNRLILM NFFQFFIWGS WLLTIGAYWF QTKQWSGTEF GAIFSTMGIA SLFMPAIAGI
IADRWINAEK LFGSFHIIAA VILFLVPLVN DPSTMFWIML VNMMFYMPTI SLSITVAYSS
LNKSNLDIVK EYPPIRVWGT IGFIAALWIV SLANFETSAM QFYVASAASL FLGIYAFTLP
KCEPLGGTSK KSFINALGLN AFALFKNARM AIFFIFAMLL GASLQLTNAY GDTFLHDFAK
LDVYKDLLAV KFPAIIMSIS QISETLFILT IPFFLRKFGI KKVMLMSMFA WVLRFGLFAY
GDPAGGLWMI ILSCIIYGMA FDFFNISGSL YVESQSEPGI RASAQGLFMM MTNGFGAFLG
SRISGIVIDK FYKIPDAAQD AIQYDWKGIW LAFAAYSLLV AVIFAIVFKY KHDPKVVESF
QH
//
