ID A0A1F3H6Y2_9BACT Unreviewed; 331 AA.
AC A0A1F3H6Y2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 10.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:OFX86244.1};
GN ORFNames=A2W86_03920 {ECO:0000313|EMBL:OFX86244.1};
OS Bacteroidetes bacterium GWD2_45_23.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1797330 {ECO:0000313|EMBL:OFX86244.1, ECO:0000313|Proteomes:UP000178053};
RN [1] {ECO:0000313|EMBL:OFX86244.1, ECO:0000313|Proteomes:UP000178053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFX86244.1}.
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DR EMBL; MENT01000008; OFX86244.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F3H6Y2; -.
DR Proteomes; UP000178053; Unassembled WGS sequence.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:OFX86244.1}.
FT DOMAIN 24..321
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 331 AA; 36152 MW; 1219BC3ECB1AD0BA CRC64;
MAKTSSKKVT DISKEKLLEM HRSMLDIRNF DNKVNRLVKR GVVPGMTHFS IGEEAANVGA
VAALEIGSDL ITSNHRGHGQ SIALGINLNE MMAEIMGKAT GTCKGKGGSM HIADLDGGNL
GANGIVGGGM GMAIGAALTQ KIKKTGKIVV CFFGDGAVNE GTFHETLNMA SIWKLPVIFY
SINNMYGIST PISSVINIDY NYRRAASYGI PGHFIEDGND LMAVYNKFEE IVKYVREGNG
PVLVESITYR YLGHSTSDPG KYRTKEEVDE WKKKDPILRF EQYLLDNKLV TKKDIEAIEK
ASEDAVEESV KFALSSPEPT LESAFEDIFA P
//