ID A0A1F3JX86_9BACT Unreviewed; 638 AA.
AC A0A1F3JX86;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Sulfatase N-terminal domain-containing protein {ECO:0000259|Pfam:PF00884};
GN ORFNames=A2W98_01450 {ECO:0000313|EMBL:OFY20986.1};
OS Bacteroidetes bacterium GWF2_33_38.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1797342 {ECO:0000313|EMBL:OFY20986.1, ECO:0000313|Proteomes:UP000177621};
RN [1] {ECO:0000313|EMBL:OFY20986.1, ECO:0000313|Proteomes:UP000177621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFY20986.1}.
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DR EMBL; MEOF01000043; OFY20986.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F3JX86; -.
DR STRING; 1797342.A2W98_01450; -.
DR Proteomes; UP000177621; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.30.1120.80; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 49..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 265..536
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT ACT_SITE 312
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 272
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 428
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 482
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 483
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 638 AA; 73923 MW; B42AAAA6D9861A58 CRC64;
MKNYFQHIIL FSKRIAFLLI LFSISRLYFF VLNFSYFETV GFWSILKSFF YGLRFDIAAI
TFFNSLFIVL HTIPGNFKSY KTYQLVLFIL FVFVNSILLG TNFIDSEYFS YTNKRMSSDI
GQLISLGDDF KNLIPAFLKD FWYTVVAFIV LIFFSCKFYP KQKVFEKSSL TIKTFVFQFL
IFAFVISISF VGFRGIELRP LNNISAAKYV RSQTIPLVLN TPFTMLKSWS KENLNSVNFY
SEEKLINIFS PITTPSQEKK FKRLNVVIII LEGFSSEFIG FISQEKSFTP FLDSLFAKSL
VFEHAFANGK RSIEALPAIF AGIPSFADNP YITSKYSTNN IKGIGTILKE KGYNTSFFHG
GINGTMGFDA FAHLAGFEKY YGLYEYPNKA HYDETWGIYD EEYLQYFAKE LTNFQQPFLS
CVFTLSSHHP YNIPQKYKNK FPKGNNKIHE SIGYVDYSLE RFFASISKAD WFKNTLFVVT
ADHTPYSLNK YYSNKLGSYS IPIVYYMPGD SLLKGKNATI TQHCDITPTI LGLLNYNEPI
FSFGKNVLDS ANSACAFNYN SVLYQLIEED FTLLFDGEKS KSLYKIKTDK LLKENLISYK
HKTRINMENK LKAIIQTYNN RMINNELIYK QPNENPEN
//
