ID   A0A1F3NXE6_9BACT        Unreviewed;       987 AA.
AC   A0A1F3NXE6;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Peptidase M16 {ECO:0000313|EMBL:OFY68915.1};
GN   ORFNames=A3G23_02760 {ECO:0000313|EMBL:OFY68915.1};
OS   Bacteroidetes bacterium RIFCSPLOWO2_12_FULL_37_12.
OC   Bacteria; Bacteroidota.
OX   NCBI_TaxID=1797365 {ECO:0000313|EMBL:OFY68915.1, ECO:0000313|Proteomes:UP000176497};
RN   [1] {ECO:0000313|EMBL:OFY68915.1, ECO:0000313|Proteomes:UP000176497}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OFY68915.1}.
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DR   EMBL; MEPC01000042; OFY68915.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1F3NXE6; -.
DR   STRING; 1797365.A3G23_02760; -.
DR   Proteomes; UP000176497; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   PANTHER; PTHR43690:SF17; PROTEIN YHJJ; 1.
DR   Pfam; PF00675; Peptidase_M16; 2.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}; Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..987
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5009494639"
FT   DOMAIN          73..124
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          271..438
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          603..690
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          756..894
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   987 AA;  114027 MW;  EC67A695D961E84E CRC64;
     MTLSSLLVFL VAFLALKPVS NLTFEPNSTE TQFMKLVEND GEFTFETVTN DPLRTRIYTL
     QNGLRVYLTV YKDKPRIQTS IAVKAGSKFD PHETTGLAHY LEHMVFKGTS HFGTKDFQKE
     KEELNKIEEL YEVYRTKTDP AERKKLYHQI DSISGVAASL AIAQEYDKMV GTIGAQYTNA
     YTSVEQTVYV NDIPSNELER WLMIEGERFG ELVLRLFHTE LEAVYEEKNR TLDNDRRKCF
     EKLFKEMFQK HTYGTQTTIG TIEHLKNPSM KKIHQYFDTY YVPNNMAMCL SGDFEPSATI
     RLVNKYFGNL KPKKIPEYVP PVENPIAQPI ESNVYGYDAE SVMLGFRFPG NSNKDVLVME
     MINDLLLNES AGLIDLDLNQ KQLVLEAGSF PVTMKDYSMH VLWGHPREGQ TLENLKQLLM
     QEIEKIKKGD FPDWLLPAVI SDYKLRLYKK YEDNSERADA LVEAFTMDMD WKNFASKISD
     LSKITKQDII RVANHYYGNN YVAVYKRTGP DTVVQKVDKP SITPVTVNRE EQSDFVKNIY
     KVKPPRLKPV FLDFKQDIKE LKIHNDVSVY YKKNEENPTF SMYYYFDFGK NVDPKIEIAV
     KYLEFLGTEK YSAEQFSQEL YKLGCQYNVF VSNEQMWINL SGLEENFQKA ISLFEQLLAQ
     CKPDQTAFLN MIDGIIKERN DAKLSKNVIL FTAMQNYARY GGDSPFTNVL SDEQLKSLSA
     EQLIFIIRSL SSLNHRILYY GTQSEKQITG NLGKHHLLPE KLFPIPVSKK FTEQDTKENK
     VFWVNYKDMV QAELMFVAKS VKFDKNIVPV ASLFNEYFGE GMSSLVFQEL RESRALAYSV
     SSRFRAPASA NECHYLTAYI GTQADKLNES LNGMLSLLDN MPLSENIFNM AKNSILGTME
     TERITKSDIL FEYEKAKKRG LDFDLRKDIY GNVQTFTLND VKKFSDEYVK NKPRTLLVLG
     SKDKINFKTL EKYGKIQELT LKDIFGY
//