ID A0A1F3NYH2_9BACT Unreviewed; 318 AA.
AC A0A1F3NYH2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Arginase {ECO:0000256|ARBA:ARBA00018123};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168};
GN ORFNames=A3G23_09425 {ECO:0000313|EMBL:OFY70522.1};
OS Bacteroidetes bacterium RIFCSPLOWO2_12_FULL_37_12.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=1797365 {ECO:0000313|EMBL:OFY70522.1, ECO:0000313|Proteomes:UP000176497};
RN [1] {ECO:0000313|EMBL:OFY70522.1, ECO:0000313|Proteomes:UP000176497}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000227};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OFY70522.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MEPC01000024; OFY70522.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F3NYH2; -.
DR STRING; 1797365.A3G23_09425; -.
DR Proteomes; UP000176497; Unassembled WGS sequence.
DR GO; GO:0004053; F:arginase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09989; Arginase; 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR014033; Arginase.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR43782; ARGINASE; 1.
DR PANTHER; PTHR43782:SF3; ARGINASE; 1.
DR Pfam; PF00491; Arginase; 1.
DR PRINTS; PR00116; ARGINASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503}.
SQ SEQUENCE 318 AA; 35716 MW; 0C78DBB4EBEB0DF0 CRC64;
MMKNLRIIQI KSEIGAGTRG ASLGVDALRI VSMEMRSDFF LKYPVVDVPN NNHLLFERNR
NPYAKRIQGI FDLYKKIAPV IKQTIEEDFF PLVLSGDHSI SAGTIAGLRQ AYPDKRVGVI
WVDAHADIHS PYTTPSGNMH GMPVAMILSE DNLHNKTNDP IPETISVWNE IKNYCSPRLP
IDSEDIAYIS VRNNEPAEDY LISHSNIRNF TTREIRQKGS IKVAHEALSY LSDCDKIYVS
FDVDSLDPTL SRGTGTPASN GLMREEAQEL LKTLLLNEKV CCFEVVEINP LVDSNNSMAK
IVFPLILEAS EVIEQRLI
//
