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Database: UniProt
Entry: A0A1F4J578_9BURK
LinkDB: A0A1F4J578_9BURK
Original site: A0A1F4J578_9BURK 
ID   A0A1F4J578_9BURK        Unreviewed;       799 AA.
AC   A0A1F4J578;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   08-MAY-2019, entry version 14.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:OGB17615.1};
GN   ORFNames=A3I64_05910 {ECO:0000313|EMBL:OGB17615.1};
OS   Burkholderiales bacterium RIFCSPLOWO2_02_FULL_67_64.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales.
OX   NCBI_TaxID=1797564 {ECO:0000313|EMBL:OGB17615.1, ECO:0000313|Proteomes:UP000177105};
RN   [1] {ECO:0000313|EMBL:OGB17615.1, ECO:0000313|Proteomes:UP000177105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U.,
RA   Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected
RT   biogeochemical processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OGB17615.1}.
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DR   EMBL; MESG01000065; OGB17615.1; -; Genomic_DNA.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000177105; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000177105};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN        8    191       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      194    295       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      360    407       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   799 AA;  86514 MW;  E7BCFE19E0C4F601 CRC64;
     MNRFQVKKVA VLGAGVMGAQ IAAHLVNVKV PVVLFDLPAK EGHKNGIVTR AIENLKKLKP
     SPLGVAADAD LIGQANYEEH MAQLKDCDLI IEAIAERMDW KLDLYTKIAP FIAPHAIVAS
     NTSGLSITKL SEVLPEAIKP RFCGIHFFNP PRYMTLVELI ATPTTEPKIL DDLETFVTSG
     LGKGVVRAKD TPNFIANRIG IAGMLATMKE VENFGLTYDV VDDLTGKRLG RASSGTFRTA
     DVVGLDTMAH VVKTLQDNLN EQTDPFYGSF GTPPVLAKLI EMGNLGQKAK AGFFKKVGRD
     IQRFDLESGE YVPAGEKADE VYGRMLKRPA AERLKLLRNA EGPQGQFLWA ILRNSFHYAA
     VHLATIAETA RDVDQAMRWG FGMKQGPFEL WQEAGWLEVA KMVQEDIDAG KALSKAPLPE
     WVFKGPVAEA GGVHTAQGSW NPSKGVFEAR RSLPVYGRQH FPELLLGEAG PKFETAGTTI
     EENDAIRVWT LDGEVLIASI KTKMHAISPD VCEGLMAAID LAEKEYQGLV VWSGDEPFSA
     GADLQAMLPA FMAVGVSAIE DAEGFMQQTM LRLRYANVPV VSAVRGLALG GGCELAVYSA
     RRVVHMESYI GLVEVGVGLV PGAGGLTYIA RRAAENAETS TGKDLLPFLT EGFTAAAMAK
     VGTSALESRK LGYVLHSDVI VPHKDELLFV AINEAKSLFN GGYRAPHKRL FPVAGRDGKA
     TILGSLVNMR DGGFISQHDF HIASLIAGVV TGGDVEPGTL VNEDYLMTLE RRAFCSLIVH
     AKTQERILGM LNTGKPVRN
//
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