ID A0A1F4KEV1_9BURK Unreviewed; 6617 AA.
AC A0A1F4KEV1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Peptidase metallopeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=A3F78_00150 {ECO:0000313|EMBL:OGB32917.1};
OS Burkholderiales bacterium RIFCSPLOWO2_12_FULL_61_40.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX NCBI_TaxID=1797566 {ECO:0000313|EMBL:OGB32917.1, ECO:0000313|Proteomes:UP000178940};
RN [1] {ECO:0000313|EMBL:OGB32917.1, ECO:0000313|Proteomes:UP000178940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the peptidase M10B family.
CC {ECO:0000256|ARBA:ARBA00009490}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGB32917.1}.
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DR EMBL; MESI01000040; OGB32917.1; -; Genomic_DNA.
DR STRING; 1797566.A3F78_00150; -.
DR Proteomes; UP000178940; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04277; ZnMc_serralysin_like; 1.
DR Gene3D; 2.60.40.3440; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 23.
DR InterPro; IPR006644; Cadg.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR041690; Cadherin_5.
DR InterPro; IPR010566; Haemolys_ca-bd.
DR InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001818; Pept_M10_metallopeptidase.
DR InterPro; IPR006026; Peptidase_Metallo.
DR InterPro; IPR040853; RapA2_cadherin-like.
DR InterPro; IPR033764; Sdr_B.
DR InterPro; IPR034033; Serralysin-like.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR InterPro; IPR010221; VCBS_dom.
DR NCBIfam; NF012211; tand_rpt_95; 1.
DR NCBIfam; TIGR01965; VCBS_repeat; 6.
DR PANTHER; PTHR38340; S-LAYER PROTEIN; 1.
DR PANTHER; PTHR38340:SF1; S-LAYER PROTEIN; 1.
DR Pfam; PF17803; Cadherin_4; 6.
DR Pfam; PF17892; Cadherin_5; 1.
DR Pfam; PF06594; HCBP_related; 5.
DR Pfam; PF05345; He_PIG; 6.
DR Pfam; PF00353; HemolysinCabind; 31.
DR Pfam; PF00413; Peptidase_M10; 1.
DR Pfam; PF17210; SdrD_B; 3.
DR PRINTS; PR00313; CABNDNGRPT.
DR SMART; SM00736; CADG; 7.
DR SMART; SM00235; ZnMc; 1.
DR SUPFAM; SSF51120; beta-Roll; 21.
DR SUPFAM; SSF49313; Cadherin-like; 8.
DR SUPFAM; SSF117074; Hypothetical protein PA1324; 3.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS00330; HEMOLYSIN_CALCIUM; 33.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 449..614
FT /note="Peptidase metallopeptidase"
FT /evidence="ECO:0000259|SMART:SM00235"
FT DOMAIN 3824..3923
FT /note="Dystroglycan-type cadherin-like"
FT /evidence="ECO:0000259|SMART:SM00736"
FT DOMAIN 3925..4025
FT /note="Dystroglycan-type cadherin-like"
FT /evidence="ECO:0000259|SMART:SM00736"
FT DOMAIN 4026..4125
FT /note="Dystroglycan-type cadherin-like"
FT /evidence="ECO:0000259|SMART:SM00736"
FT DOMAIN 4357..4479
FT /note="Dystroglycan-type cadherin-like"
FT /evidence="ECO:0000259|SMART:SM00736"
FT DOMAIN 4480..4581
FT /note="Dystroglycan-type cadherin-like"
FT /evidence="ECO:0000259|SMART:SM00736"
FT DOMAIN 4582..4682
FT /note="Dystroglycan-type cadherin-like"
FT /evidence="ECO:0000259|SMART:SM00736"
FT DOMAIN 4683..4783
FT /note="Dystroglycan-type cadherin-like"
FT /evidence="ECO:0000259|SMART:SM00736"
FT REGION 228..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2227..2257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2227..2244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6617 AA; 690078 MW; 8B350D4F0BC925B8 CRC64;
MTRGAVITHE NEPSANLGKE KSVALDLGNA KDVLQAGTGE QGARLWGGVG NDVIYGANNS
DKLYGDADDD LLIGYGGDDA LYGGAGKDEL SGGEGRDFLD GGDQVDHLQG GYGADVLYGG
EGDDNLMGDA SYLEGTDWYP VGTDESKMAG DYLYGGVGND KLWGNNGDDY LYGGVGNDGL
YGGLDNDHLW GETGQDTLMG WKGDDYLDGG ADNDALYGDE NNDVLYGRAG DDNLDGGEND
DILDGGDDND VLTGGGGKDI LRGGAGNDTL YGDSGESADD ADILEGGSGN DTLNGGGMSD
MYVFGVGDGQ DVVQDDGSDG SRNTIVFKFD KSEVRQVRRD GVDLHIDYGQ SDSVLVQGFY
GSNAFGLGYQ GDGAQMIDQG EAQARVAEIR FEDGTVWGVE QILAMAPAPV PGEVPVDPFA
SLKPLYFIDA LLSREDVKAA DKHTLNFGFA TSFPHGENKA MLFTEPQKQA VRDALARFSA
VLDLKFTEVQ DGATADLTFY MDDLTSVGMG AFAGYATPST GDIHLNSARY GELITNEFGE
TSTRDSLNAG QSGFVTLLHE IGHTLGLKHP FEAPLLPKAE SNSTNTVMSY TRVGDTVADL
AMFDVAALQY LYGVAKDRRM GDDVYTFANR YVDDGAGVDT FDASSETQDV FVDLNPGAWL
HSGAKDASIL AAGQAFIGFG SQLENAKGGA GNDALLGNAA NNVLEGGAGT DSLSGGAGDD
TLAGGEGADA YFFSVGAGTD TVNESARDSV IVINGVSVYS LYYFEGALYY GPQGDRVVLD
LAQVVELVVD GVSYTGAQVQ AALGTVVSET GDMVLSGDQD RGRLLGSGDW RITGNELANV
LHGNAGNNTL EGGAGDDTLN GGEGDDALLG GDGNDVLAGQ GGRNYLQGGD GADTYVLKNG
HALIQDEVGL NVLRLDDGAV NLQADFNSAD FGLTMRLVEF GTSGAGGNAQ AEALVSSPNS
LVAQAASLVA GQYTLMTTPS SSALLQGGLD ASFDEVQDSH GNRLSWVQLV QQARVSRDET
IHAEINRRWY GSDYGDSLES SQSAYTYVGG QGNDHITATG GGNTFLFAKG DGTDFMRVVD
AGAGVSGNTL RFGPGISQAD ITLGVDSLLI RVGSDPQDCI RIDGFNPDDV YALRAVDRFE
FVDGTVLTYA QLLQRGFDLQ GQDWNDRLQG TNVVDRITGG RGDDTLTGGA GGDTYLYSMG
DGADWIREAA TGAVESDVLK LVNVAAADVQ VWRGQQDVWL TFAAEGGLTE SVLLEGQLRG
EGRGVERVEF SDGTVWSAQQ LADRAQWSPM SSVRVEGTDG VDSLSGLDGA DTVLGHFGND
VLEGGYGDDL IYGAFEYDQW WYGEGDGGEG GDGGEGGNAP GFTDDDTLYG GAGNDILDGG
YKADRDQLLG GSGDDTYVFR RGSGDDVVIE SSDQGNADRI RFESLDSDSV MRSRSGNDLV
LSLDNGSDRL TIRDFFSSPT CVVEFFDFYD ITLTSEEMRL EVLQGGGGND TILGYASDDF
LLGKGGNDRL EGLDGNDALT GGQGDDTLDG GAGSDIYHFG LGDGRDRLVD TGAEGDDVLR
FGEDVDRADV TAIRLEDDLL VIIRSTGDRV TLAGWFGSGG RTVESVAFAD GTVWSAQELE
ALAQVPGVPS GEADYLVGTS GADSLGGLQG DDEIYGAQGN DTLEGGAGDD TLVGGAGDDS
YVYQAGDGSD TLMDQGLGDA DFLLLGDGID PGTVRVTRDD QNLYLDLPDG NSITVWASYT
DLANTLAGVR FSNGVEWARS ELEARAVAAT DGDDFIVGTA AADALAGGEG ADTIKGLDGN
DTLAGGHGSD RLYGGQGDDT YTFASGDGSD QILDEGGADT LRFGPGISPN DVQVIKTSNG
QLVLRHYGTG DSVSFEAVSA YRQHQGYVLV GSSVETVQFD DGTVWSSDDL VRYALAETGV
GGDYIQGSER GDILDGLGGN DVLQGGLGDD RYVFNRGYGS LRIQDGDATS GNQDRLLLGN
GITPEELHLY RNGDNLLVQI SGTEDQIEIT GYFGDAGQGV IEVIQFADGM RWSSADVNQR
LLVRAGTEAS ERIDGSGRDD AMTGGAGDDY LYGHDGGDGL DGGTGADYLY GGAGDDTLSG
GASSGTDLNN EALYRDQYYY WHYYRHDVLA GGAGDDTYLL RPGDGYDEIN DSQGSNRIVL
ADGMSAENII IATIPYGAKA GQTKIDYGTG AVFLNVDSRI DSIESADGVV INASNWSDYY
VNTSSGTSGN DTLNGGTGPD QLSGSNGEDL VMGGTGRDTV YGDAGDDRLF GDAGDDQLND
SSGSNYMSGG SGNDVIYGVG YLSGGEGNDQ LSGRGIFEGG RGNDTLVLGG VSTVVYNRGD
GFDAINHSYG GSETWIRTDL LAAEVEILGG AVDGLDMPWT LRVKASGEGL SGIQIATGVV
FGDGMVWTAA ELATRVHLPA PLASSGHDLM LGDSGRDVLD GLDGNDSLAG ANGDDVLRGG
VGNDKLLGGS GDDTLEGGVG HDELVGGAGN DWLQGGEGLD TLIDTSGNDT LDGGAGDDSY
SVGAGQKTVV FGPGSGNDQL YSQYNAESPS RLIVQFADGV APDDIVLTGN YNSLIIGLAN
HSGDTLNVSN WFQGGILQPV VELRFANGTV WGPEALADKA AALNPNEGDY RDNLIVGRAN
ADTLRGYVGN DSLQGMGGDD TLVGGEGDDL FDGGLGNDRL ELQGDAYGQD QGRDTVVFGF
GSGNDTVASA GGLDLIQLQP GVRYEDLRIE VIGGDLLISL AGSTDSLRIE GWAYTYQNTA
RLERLLFADG SSFDLTRPPF SILIGSAGRD VISSDVASPF NDRLHGLDGN DQLYGGGGND
TILGGAGSDS LAGGTGGNTL DGGLGNDTYY VQGGDDTVVL GYESGQDTLS HQYMWQSSPA
IRFERNVLPQ DVVIKDVSYN FYYNTGSFTV ALSGSTAVLR NYQFQLDADM SPINIKPFVF
ADGTVVESAE LFPRFYRNTA TASYDTLIGS PRDDTLAGLA GNDLLVGGVG DDNLDAGAGD
DQVFGGTGRD FIIGGAGNDT LTGGVGQDTY HFDFNFGNDL IQVETSQAED ALDVVEFGPG
IAPSDVTVSV LNGYLQFTLV GGAGQARIAH NNHRYGASGG GMKLAEVRFQ DGTVWDAAAV
TARILQQTAL NDILVGSSGR DVIDGLDGND MLDGLAGSDL LAGGSGDDTL DGNEGSDQLF
GNGGNDSLMG GTGHDLLEGG TGDDSLVGGA GSDVYRFGRG DGNDVIQDFG VGPQEQDTLV
FGPGIGLADV SREVVDSRIV LRIQGGEDSV SITGEGHTQP GIERVRFSDG TVLDPLTWAV
LSSQVLLSVD SGWLNVGADS QLETLEVGVG LLPSGVESVR DNADLLVRAG SDGIRFVGWF
NEPVRQAVLQ VVFANGTVWS AEDLTRMASR QDGTDGDNVL RADPAFPSRL EGLGGNDQLV
GSVGDDELLG GGGNDILDGG QGADRLEGGM GDDFYIVDQR DTVVEQAGGG NDTVRMLATS
DVLVQGEIES YEILGNAAIN LYGNEVANRL VGTTAVNRIE GGLGNDTLDG GLGADVLVGG
LGDDRYVLDN GADTVTELAG EGNDTVAASI SYTITDDAHI ENIELLGSGN LTATGDTQAN
VLRGNAGRNL IKGLAGDDTL DGGDGSDILE GGMGNDRYVV NSAADQIIEL ADEGNDAVEA
SASYALSENI ENLTLMGQAA IDGRGNALDN RLQGNAGANV LDGGLGDDTL DGGLGNDMLS
GGAGGDGYVF GRGYGEDLVF ENGSAVGVDT LVFGTGLVAA DLLLRRNGDD LIISIRDTLD
RITVRQQWQS AGQIERFVFD GGMVWGLTEL EQALTNSGTN TVPTVSQPAL DQLAAVGQTF
EFSVATVFRD LDAGDRLIPQ VMLLNGDPLP RWLSFDPVSL VLRGTPGDGD VGTLQLSVQV
SDSAHQVASD VFDLTVRNPN DTSPLVLNAL TDQAVRQNDR LEFVIPDNSF VDLDVGDRLS
YTACMLDGQP LVRWLSFDAE RRMFTGTPDK DDVRTVTVSV TATDGRGRSA IDSFEIRVDD
INDAPRVMRL VDDVAILQGQ TVDLTLPADL FVDREGGAVG VAVSLLNGDP LPSWLQWTPA
TGRIYGTTSS DSVGVTSVRI VGTDPEGLSA YEDFDIVVGD VNDAPVVRNP ITPFSFVEGN
RIFTTIPRNV FSDPDLGDAM TFRLETLSAP EHAKSSFYLS SSGELNFGSN QSNGFVYSAL
DYWDIGTWNF RITAQDRLGL TTSTDFTLNV QGAGQNHIPV YANSTTPWSA GSYFYNNSRG
LVSWSSAMPD KFVATMTEPV AIQLPRFVDV DGDTLSYSVL PINTQSSSDW QYDSATAKLS
YVGTAPAPRK QGFDVIVSDG HGGASMTSFM VYANRKPVLQ GVPEIFVREN QAFSFTLPDS
IASDPDGDTI FLESTNYYVG SYNNPLTQNT EWAFGYDSDT RTFSGNPGDF AVGTYYYQLR
ANERGISSGT QTPDDLADSF VYSPVTTVKI TVLNEYDAPV LIAPIADKVV MENNYFQLYS
SSAFYKIDRD QTLTYAFSLA NGAALPSWLQ FDTASGVLYG TPGSTQVGSY SIRVTATDIV
GSRLSDEFDL TVALSPDNHA PLLVTPVVDQ IYRSGQDFSF QVPRNTFAEL DPGDSLTYQA
VQDNGNPLPS WVSFNASTLV FSGAVPIDQR APTEIRLIAK DGSGATAFDV FSLGIDEKGL
PPIVAEPVAD QSTDEDGLFS FALPQGLFND PSPATGMVLS ATLFNGSALP TWLSFNAVSG
QFEGTPLNED VGVLQVRVTA TKPGGAQASD VFQLTVRNTN DAPLVAGESF VVDGDGVLRL
SSTQLLANDS DVDPTYDTLV VSSVSDAQNG SVSLSADGQV VFAADPSYQG PAAFSYTVGD
GHGGFTTGQV LIDVSRQDLA PVALDASVQL QEDASHTFTI QEFGFSDSDG PAQALSVVVS
APSVGTLLFN GVAVLVQTVV QRADVDAGLL VFSPAENANG NGYATLSFRV DNGKLSDNIG
VLSLDVLPVN DGPNAQNDHG AVEEDALQPL TGSLLDNDSD IDAGTSLSVR DPGSFVGNYG
TLILEANGAY SYQLNNGLAQ VQSLALGERL EESFDYSVTD GEAQATAKLT VTITGTNDLP
GVQVDSGWIN EEDRSALEIH VLANDHDVDH GSVLAIANPG GRVGLYGQIT VGADGAALYQ
LDNELPEVQS LGKGQELVDH FVVQVGDGFG WVDSAIDIHI QGQNDAPVSV ADAALVQEDG
QTQVSGNLLS NDTDVDHGTV LELVDPGVRK GMYGTLTVDA SGAYSYELDN ALSAVQALAQ
DAIVTESFSY EVSDMSLTAT SQLLVSVRGT NDGPIAVADT AAVAVGVLSL AEGNVLLNDT
DADAGAVLQL TNVGSQTGGY GVLQLTADGH YAYAIDSASA KIRALAAGET VVDTFSYEIS
DGAASSTAQL AITITGQNDA PVVQADAANV QEDVIGLAMG NVLDNDHDPD ATDTLQVFNA
GSLVGQFGTL SLEADGSYTY ALDQQASAVQ ALRGGESYQE AFSYSVTDGT ITEQASLLVT
VLGTNDAPVG EDDFSDMQVA TPNATVGNVL LNDRDIDLGT VLSVSNAGHM AGRYGVLELD
ANGNYRYVLD TALPEIQALP VGAELTETFT YTVQDDDASQ MLASSGNLFI RIAGSNAATG
RISGYVYLDA GDDGVRNSEA AIVGVTVTLS GSNDLGGLVN AQAVTNAVGY YEFADLRPGN
YTVTESQPSG YADGKETAGS TGGFAGADTI AAIVLAAGEH SQENNFGELP AALSSIGDLV
FLDCNNNGIQ DAGEKGVSDV TVKLLNATGA VIDTTTTSAS GQYLFGGLGA GNYAVQIVAP
VGYGYAKRDQ GANNALDSDV DTTTGKTVLV SLGAGVSDMS WDAGLVSTPV RITYSFNGNT
ATDGTDGNSR SYTDAATGVS VTANAWSRDK IVGTWSKAYL GAYAGGLGVT DKSEGCGCGG
THTIDNNGRD NYVVYQFSQA VTVDRAYLGY VFGDSDATVW IGRTDAPITN MSNSVLTALG
FSEVNVGAGS TRWADINADQ ISGNVLVMAA KQGECNDFFK IGKLEVSTTV CTPKPEMKAS
MGSRVWCDSN GNGLQDSGEL GVSGVAVNLL NGNNQLVASA TTNASGDYSF TALTPGSYLV
EFVKPVAYGG FTLANQGCND ALDSDADAVS GRSALTTLVA GENDVNWDAG LRPSTVTRTY
RFSGKTATDG TDGNTRAGTV DGISVTASAW SRDKANGAWA KAYLGAYSRG YGVTDRSEGK
GRGNTHAVDN NGCDNFVVYQ FSDEVVVDKA YLGYVSGDSD ISVWIGNYAG TIASMSNAVL
SGLGFTEVNS GGGAARWADL NANGISGNVL VIAAKTGESN DCLKIEKLQI SATSKVVTPI
VIDLDGDGLK TTSWLNSTGS FDLFNTGSPI KSGWLSGDDG FLAVDKNANG KIDSLSELFG
GFNQGEGFAQ LAGYDSNGDG MVNVMDTGFA ELRIWRDRSG DHVTDSGELM TMAQAGVENL
NLGYQLAPVL DENGNLHGES SSASLSSGQL VKMTDVYFAV SPVDAANEVA LPTLDELLTN
GSFLSGFASS SWPGDNPAGT AASYLLGASL DGQAQMDSQV QNLVQAMASF APSGAGLTTV
SAANQSTFES LLAANLT
//