ID A0A1F4PLQ4_9BACT Unreviewed; 452 AA.
AC A0A1F4PLQ4;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Hemolysin {ECO:0008006|Google:ProtNLM};
GN ORFNames=A3F66_04285 {ECO:0000313|EMBL:OGB84574.1};
OS candidate division TM6 bacterium RIFCSPHIGHO2_12_FULL_32_22.
OC Bacteria; Candidatus Dependentiae.
OX NCBI_TaxID=1802375 {ECO:0000313|EMBL:OGB84574.1, ECO:0000313|Proteomes:UP000178609};
RN [1] {ECO:0000313|EMBL:OGB84574.1, ECO:0000313|Proteomes:UP000178609}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGB84574.1}.
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DR EMBL; METJ01000012; OGB84574.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F4PLQ4; -.
DR Proteomes; UP000178609; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR002550; CNNM.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR044751; Ion_transp-like_CBS.
DR InterPro; IPR005170; Transptr-assoc_dom.
DR PANTHER; PTHR22777; HEMOLYSIN-RELATED; 1.
DR PANTHER; PTHR22777:SF33; UPF0053 PROTEIN YEGH; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01595; CNNM; 1.
DR Pfam; PF03471; CorC_HlyC; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM01091; CorC_HlyC; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
DR PROSITE; PS51846; CNNM; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU01193}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU01193};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW ProRule:PRU01193}.
FT TRANSMEM 14..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..198
FT /note="CNNM transmembrane"
FT /evidence="ECO:0000259|PROSITE:PS51846"
FT DOMAIN 219..277
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 280..337
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 452 AA; 51227 MW; F1BB7397D939769A CRC64;
MDQSYSYILY YQGLGFIFTL ALCALFSFIE TSITALRIFK LKELAESTKK YSSLFELLET
QPNKILFTIL IANNFASASC TGLITAIMSE LFIRLNWSEG LGLTAGIAIA TCAIVVFGEI
IPKNIARSQG DRLLKYTLGI TYVTYHLLKP FVIAVTNFAN LIMSPFVKNH NLEIAPSEQE
LSFLIDYTNK KGLIDKHKTS MLLSIFKLSE KSIKEIVIPE PEMICIQLDS TVKDTLEIYK
KYQFSRLPVY ENTMDNIVGI IYIKDLIYKN LSEDTKIQKF IRPVMFVPES MKVSQLLRQF
KETKKHMAIV LNEFGGIEGL VTLEDVLEEI VGPIIDEHEK APDDIIRFND QLLVNASINL
EELKKVLNIE FETKAISLGG FIIETLQRLP SIGESLNYKD YQFRIENATP KKIIKVMISE
RNLKGDSYEK NADVHAVSKH PVPASGTRKI SS
//
