ID A0A1F5B7S2_9BACT Unreviewed; 469 AA.
AC A0A1F5B7S2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Na+/H+ antiporter NhaC {ECO:0000313|EMBL:OGD26606.1};
GN ORFNames=A2028_03465 {ECO:0000313|EMBL:OGD26606.1};
OS Candidatus Aminicenantes bacterium RBG_19FT_COMBO_59_29.
OC Bacteria; Candidatus Aminicenantes.
OX NCBI_TaxID=1797276 {ECO:0000313|EMBL:OGD26606.1, ECO:0000313|Proteomes:UP000179239};
RN [1] {ECO:0000313|EMBL:OGD26606.1, ECO:0000313|Proteomes:UP000179239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGD26606.1}.
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DR EMBL; MEYE01000092; OGD26606.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5B7S2; -.
DR Proteomes; UP000179239; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF3; MALATE-2H(+)_NA(+)-LACTATE ANTIPORTER; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..454
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 469 AA; 49604 MW; 8DA4370BD3045BE1 CRC64;
MIVERAKTPS LGLALLPLIS MALLLGVGYG IYGIRPQVLL IAAAFLTGCL GVLLKFRWED
MQKGIVESIT KAMPAILIML TVGVLIGSWM ASGTIPMIIY YGLKLISPKF FLVTACLVCS
ITALATGTSW GTVGTVGVAF IGIAMGLGLP LGLAAGAIVA GAYFGDKMSP FSDIPNLAAV
TAGANLFDHI KHMMWSAVPG WLLSLAVYFV VGLKYDAGTV STDTTNLILD TLRRNFRFNL
LLLLPMLIVL YLAFAKKPTI PGMLLSSLTA AFLAVVFQKE SIVRIAQAVN SGYPAATGVE
SVDTLLTRGG LMSMMETQLV AFTAFSFGGI MQKTGMLGVV LDRIMRVARK VGSLVMVTIG
SCVVTALVTG SSYLSVIIPG ELLGPAFREK RLAAKNLSRI IDECGGIIVP LVPWSMAGVY
ITGALGVPVL SYLPWAIASW AALLILAAFG FTGFTMAPRK REDETQAGS
//
