ID A0A1F5BAH1_9BACT Unreviewed; 352 AA.
AC A0A1F5BAH1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000256|HAMAP-Rule:MF_00081};
GN ORFNames=A2V57_06360 {ECO:0000313|EMBL:OGD27605.1};
OS Candidatus Aminicenantes bacterium RBG_19FT_COMBO_65_30.
OC Bacteria; Candidatus Aminicenantes.
OX NCBI_TaxID=1797277 {ECO:0000313|EMBL:OGD27605.1, ECO:0000313|Proteomes:UP000177619};
RN [1] {ECO:0000313|EMBL:OGD27605.1, ECO:0000313|Proteomes:UP000177619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000256|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-
CC Rule:MF_00081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGD27605.1}.
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DR EMBL; MEYF01000065; OGD27605.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5BAH1; -.
DR STRING; 1797277.A2V57_06360; -.
DR Proteomes; UP000177619; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00081};
KW Stress response {ECO:0000256|ARBA:ARBA00023016, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00081};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00081}.
FT DOMAIN 108..329
FT /note="Heat-inducible transcription repressor HrcA C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF01628"
SQ SEQUENCE 352 AA; 39684 MW; FFE4EC8CA3E7A7EC CRC64;
MVTSVLRDKD KKVLILVVES FVRHGRPVSS GSICQTRRIT ASPATLRNIM AKLEEMGFLS
QPHTSAGRVP TDKGLRYYVG GLIAEKALPE ERVPLIQGEF PNRTADFDSL LTQACRILAD
SSDNMGFVIS PHIFRLPFEH LRFVKISDRR ILVILVTPFH MVLTETLESS LPLTQAELDR
ASQYVNQNFR GKTIFAVRDA LLRELPKHRI KYEDTLNKLL DLFKASIDKE EGESRIFLQG
TSRLLGKADL FDMDKLRALF QNFEEKAALV RLLSDFISLD RVKVLIGAEV NFPKVEDCSL
VLSHYGYSNQ VLGTLGIIGP KRIPYEKIIP LVDRMAKSLS LAITVFGREV SL
//
