ID A0A1F5BB42_9BACT Unreviewed; 245 AA.
AC A0A1F5BB42;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=NAD(P)H-hydrate epimerase {ECO:0000256|ARBA:ARBA00012228};
DE EC=5.1.99.6 {ECO:0000256|ARBA:ARBA00012228};
DE Flags: Fragment;
GN ORFNames=A2V57_00320 {ECO:0000313|EMBL:OGD27821.1};
OS Candidatus Aminicenantes bacterium RBG_19FT_COMBO_65_30.
OC Bacteria; Candidatus Aminicenantes.
OX NCBI_TaxID=1797277 {ECO:0000313|EMBL:OGD27821.1, ECO:0000313|Proteomes:UP000177619};
RN [1] {ECO:0000313|EMBL:OGD27821.1, ECO:0000313|Proteomes:UP000177619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-NADHX = (6S)-NADHX; Xref=Rhea:RHEA:32215,
CC ChEBI:CHEBI:64074, ChEBI:CHEBI:64075; EC=5.1.99.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000013};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-NADPHX = (6S)-NADPHX; Xref=Rhea:RHEA:32227,
CC ChEBI:CHEBI:64076, ChEBI:CHEBI:64077; EC=5.1.99.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000909};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGD27821.1}.
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DR EMBL; MEYF01000058; OGD27821.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5BB42; -.
DR STRING; 1797277.A2V57_00320; -.
DR Proteomes; UP000177619; Unassembled WGS sequence.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1.
DR HAMAP; MF_01966; NADHX_epimerase; 1.
DR InterPro; IPR004443; YjeF_N_dom.
DR InterPro; IPR036652; YjeF_N_dom_sf.
DR InterPro; IPR032976; YJEFN_prot_NAXE-like.
DR NCBIfam; TIGR00197; yjeF_nterm; 1.
DR PANTHER; PTHR13232; NAD(P)H-HYDRATE EPIMERASE; 1.
DR PANTHER; PTHR13232:SF10; NAD(P)H-HYDRATE EPIMERASE; 1.
DR Pfam; PF03853; YjeF_N; 1.
DR SUPFAM; SSF64153; YjeF N-terminal domain-like; 1.
DR PROSITE; PS51385; YJEF_N; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 9..221
FT /note="YjeF N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51385"
FT NON_TER 245
FT /evidence="ECO:0000313|EMBL:OGD27821.1"
SQ SEQUENCE 245 AA; 26000 MW; 0BE366278800D627 CRC64;
MKILTSVEMK DIDRTAIEEL GIPGIVLMEN AGLRVARALK GRFPDIAAET IVVVAGKGNN
GGDGFVAARH LFNSGAKPEV LLLAAKDEVK GDAAVNLAVA LKMGISVTEV RTAAAWKKVR
IAVFHASVIV DALFGTGLVK PLDEIFAMAV EDINKSSAFK LAVDIPSGLS ADTFETIGPS
VDADLTVTLA APKIAHIFPP AAERVGDLVV APIGIPPFLF EKPGLRLELV EETALRPFFR
KRKKD
//
