ID   A0A1F5CBB0_9BACT        Unreviewed;       742 AA.
AC   A0A1F5CBB0;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   22-FEB-2023, entry version 14.
DE   RecName: Full=Transketolase-like pyrimidine-binding domain-containing protein {ECO:0000259|SMART:SM00861};
GN   ORFNames=A3I30_02615 {ECO:0000313|EMBL:OGD40139.1};
OS   Candidatus Azambacteria bacterium RIFCSPLOWO2_02_FULL_44_14.
OC   Bacteria; Candidatus Azambacteria.
OX   NCBI_TaxID=1797306 {ECO:0000313|EMBL:OGD40139.1, ECO:0000313|Proteomes:UP000177197};
RN   [1] {ECO:0000313|EMBL:OGD40139.1, ECO:0000313|Proteomes:UP000177197}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGD40139.1}.
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DR   EMBL; MEYV01000011; OGD40139.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1F5CBB0; -.
DR   Proteomes; UP000177197; Unassembled WGS sequence.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          402..590
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   742 AA;  81851 MW;  5943C2E27FF0A5A4 CRC64;
     MRKDLDRGTY LDLYRYLLLA REVEGKVRAE FGQNERASLV PSVALTSFGE EAIGIGSALA
     ADPKKDWIAI GHRAIGACFV FGLTPEEYLS NHFLRSFSPM GGRDGNIHFG FPDRHIIRFI
     SHMGANVPAA CGVADALKYV YIMEKTGEAL PVVLCYFGDG AASQGAIHEA MNYAGARNLP
     VIFVVDNNRT AIGTPYEAQT GAFSIADRAR GYGFHGEIAN GNDVLDVYHR TRQAIERARF
     LSARTREIKT LNLLRAPSII ECLTLRMSGH NETEKVPYVN SQEYNEWIGR DPCGFYRNQL
     LKMKKSEILA KVLDPKERER ISVPEFSEEE LAGIDAEVKV MVQAAYDKAA QSSKTTIENV
     SLSVYPQKYV ADNNPNHFDQ EPTAAFSIIN RKLTKEDREG TITLADAIKD ALHMALENDP
     KVRIFGEDVC GAYGKKGGVF GITQGLPEKF NDGDFSGLSG VDRVFDTPIA EGAIIGSAIG
     HAIAGLVPIC EIQFMPFIST CSFSQLIDMA STYYFTTRHP LGFVVRTAYG LGFYGGHFHS
     NSLTEAMFYH TPGLKIVCPS TPYDAKGLLL QALEEKAPVI FMESIWGYSR VRGQVDKNYY
     KVPIGKAALR RKGSDLTVVT WGARMYFNSV LPAVLETEKS GASIDLIDLR TLKPLDMAAI
     YNSVAKTCRV LIAGEDIANG GIAESIMAKI IQEYPYIRGK VLGAPDTPIP QFEDFYAPNM
     QKVLEAIEKL TDRRPQDYAS DA
//