ID A0A1F5CQS3_9ARCH Unreviewed; 683 AA.
AC A0A1F5CQS3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=A3K69_03620 {ECO:0000313|EMBL:OGD45222.1};
OS Candidatus Bathyarchaeota archaeon RBG_16_57_9.
OC Archaea; Candidatus Bathyarchaeota.
OX NCBI_TaxID=1797382 {ECO:0000313|EMBL:OGD45222.1, ECO:0000313|Proteomes:UP000177200};
RN [1] {ECO:0000313|EMBL:OGD45222.1, ECO:0000313|Proteomes:UP000177200}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGD45222.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MEZI01000050; OGD45222.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5CQS3; -.
DR Proteomes; UP000177200; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd01028; TOPRIM_TopoIA; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR023406; Topo_IA_AS.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005739; TopoI_arch.
DR InterPro; IPR006171; TOPRIM_domain.
DR NCBIfam; TIGR01057; topA_arch; 1.
DR PANTHER; PTHR11390:SF26; DNA TOPOISOMERASE 1; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS00396; TOPOISOMERASE_I_PROK; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:OGD45222.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..141
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 351..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 75081 MW; 4B64E1E1AEEEAD94 CRC64;
MLLVTEKPSS ARRIAEALDE GGRPETRRAG DVTYYLAARC GNELVVVSAL GHLYTLVQRG
EGWTYPVYDT AWVPVTQAGK GHGKAGAHIR AIRSLAEGAQ GFVSACDYDM EGSLIAYNVL
RYAVGEHSLP RAGRMRYSTL TREDLNRSWE ARSRALDYPV IAAGKARHEV DWLFGLNLSR
ALTLAVRNAS GLSRTLSVGR VQGPTLGFVK AREDEICSFV PVPYWRAQAE TEIDGERYPL
EYSEPRLERE TNAKELARAC RGQVGRVTGV HEETERRPPP PPFNLGDLQR EAYRVHKLSP
SATLATAEKL YLGAYISYPR TSSQRLPSSI DIKDILGKLS RSPTYAAYAE KLLSRKTPRP
RQGKKDDPAH PAIHPTGASP RRLGDPESKV YDLAVRRFMA CLAGPLVTER ARADVDVNGH
LFFLSGSLIR ERGWLEYYPY VKEGERRFPK LAVGSSVPVT KLSTGRAYTK PPQRLNASSL
LGLMESVDIG TKATRTEIID TLSKRGYTEG QSIRITDLGY GVVETLERHC PDILSVGLTR
GLESDLEAIQ TGGVEVERVL EKAQETLGPI LARFRENEDR IGEEIAGTLR GAARKEGYLG
SCPSCGAGDI TLGRNSKTGA VYASCSNRAC GQSYGLPQKN RFYSTGKSCA ECGAPVIKMY
FHRKPLELCV NPECPSKGGR RDG
//