ID   A0A1F5FTQ9_9BACT        Unreviewed;       471 AA.
AC   A0A1F5FTQ9;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00018753};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE   AltName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN   ORFNames=A2572_02235 {ECO:0000313|EMBL:OGD83006.1};
OS   Candidatus Collierbacteria bacterium RIFOXYD1_FULL_40_9.
OC   Bacteria; Candidatus Collierbacteria.
OX   NCBI_TaxID=1817731 {ECO:0000313|EMBL:OGD83006.1, ECO:0000313|Proteomes:UP000179237};
RN   [1] {ECO:0000313|EMBL:OGD83006.1, ECO:0000313|Proteomes:UP000179237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- FUNCTION: Is required not only for elongation of protein synthesis but
CC       also for the initiation of all mRNA translation through initiator
CC       tRNA(fMet) aminoacylation. {ECO:0000256|ARBA:ARBA00003314}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|RuleBase:RU363039}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGD83006.1}.
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DR   EMBL; MFAQ01000032; OGD83006.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1F5FTQ9; -.
DR   Proteomes; UP000179237; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00814; MetRS_core; 1.
DR   Gene3D; 2.170.220.10; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR023457; Met-tRNA_synth_2.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 2.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039}.
FT   DOMAIN          5..145
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          150..360
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
SQ   SEQUENCE   471 AA;  54045 MW;  21CAAAA7A9AEE1AA CRC64;
     MDKFYITTTL PYVNSDPHIG FAMEIIRADV VARVKRARGN QVWFNTGTDE HGQKIYQKAV
     EEGVLPQEYC DRFAEKFKGL KSKLNLSNDT FIRTTDKKHI KAAQDFWTAC FNNGDIYKKN
     YQVKYCVGCE LEKTDSDLVD NKCPDHPNYE LELRDEENYF FRFSKYQEKL LDFYKKNPDF
     VCPDFRMKEI TNFVESGLSD FSISRLKSKM PWGVEVPGDR GQVMYVWFDA LVNYISVLGW
     SSTASAEFGE YWPGVQVCGK DNLRQQSAMW QAMLMSAGLP NTKRIYVNGF ILSDGVKMSK
     SLGNVIDPLE WVEKYGTDAV RYFLLSSISS FEDGDATEER FKEVYTAGLV NGLGNLTARV
     AAMIEKAETE FEDAVNTPDN EVFRAVEEYN FALAIELIWK KIKTADTIIN EKKAWSLTGV
     EQKEVLSELV RIIRQVAVDL DVFLPEMAKK IQNQFGGEKI TKSEHLFARL K
//