ID A0A1F5H1T5_9BACT Unreviewed; 303 AA.
AC A0A1F5H1T5;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=A3B54_05675 {ECO:0000313|EMBL:OGD98122.1};
OS Candidatus Curtissbacteria bacterium RIFCSPLOWO2_01_FULL_42_50.
OC Bacteria; Candidatus Curtissbacteria.
OX NCBI_TaxID=1797730 {ECO:0000313|EMBL:OGD98122.1, ECO:0000313|Proteomes:UP000177039};
RN [1] {ECO:0000313|EMBL:OGD98122.1, ECO:0000313|Proteomes:UP000177039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGD98122.1}.
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DR EMBL; MFBT01000042; OGD98122.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5H1T5; -.
DR Proteomes; UP000177039; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251}.
FT DOMAIN 71..275
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 303 AA; 34294 MW; 6AE310E10AD771FC CRC64;
MFKSSRFLLV LLIILPVAIT TVVISFKKTP ENLPPEIINR INVFQPQEQT AVTYLKETVE
NVLIGTKGTY GVAIKNLKTG ETYYLNEHRI FESGSLYKIW VLATAFDQIK NGTLKQDEVL
SQDISVLNEK FNIDAGSAEI TDGKITLSVK NAIEQMIVTS HNYASLLLSE RIKLSAVSAF
LEKYNFDEST ISEPPKTTPY DIALFFEKLY KGELANNENT EEMLTIFKRQ QLNEGMPKYL
PQNVKIAHKT GEIGWAKHDA GIVFSDSGDY IIVIMSESDS PRQAQENIAL VSRAIYDYFI
FRR
//
