ID A0A1F5H7M3_9BACT Unreviewed; 566 AA.
AC A0A1F5H7M3;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=RCK N-terminal domain-containing protein {ECO:0000259|PROSITE:PS51201};
GN ORFNames=A3B54_02070 {ECO:0000313|EMBL:OGE00167.1};
OS Candidatus Curtissbacteria bacterium RIFCSPLOWO2_01_FULL_42_50.
OC Bacteria; Candidatus Curtissbacteria.
OX NCBI_TaxID=1797730 {ECO:0000313|EMBL:OGE00167.1, ECO:0000313|Proteomes:UP000177039};
RN [1] {ECO:0000313|EMBL:OGE00167.1, ECO:0000313|Proteomes:UP000177039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGE00167.1}.
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DR EMBL; MFBT01000005; OGE00167.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5H7M3; -.
DR Proteomes; UP000177039; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 29..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 323..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 408..533
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 566 AA; 61813 MW; 422D532391AA8476 CRC64;
MPTAFLELAS VLVLATIIGI ILRSFKQPLI LAYIFSGIII SLFGFFKNID KSVFDLLSNL
GIAFLLFLVG VELKTQDLKY VGKTAIFTGL GQIFFTLVVG FILLSGLGQS PIEAAYIAFA
ITFSSTVIII KLLSEKHDLQ SLYGKIAIGY LLTQDFVAIS ALMILSGFGQ GGHLPSMFSI
LLIFVKGLLL VGLTYLASKF ILPILFKLTS TSTELLFVAA IAWAFLLSAV GAIAGFSIAI
GAFLAGVAIA SSAYRLQISA RVKPLRDFFI VIFFILLGAS ISVSASRVMI VDILVLSLFI
LFGKPLIMLA IMKTLGFRNR TAFLSSVTGA QISEFSLILL TTGVALGHIS GDTLSLVAGV
GIVTIALSSY LILYGERIYR FLEKPFLVVL PQVAREPYVL NREKLTDHLV LVGGEQMGWD
ILEFLKTKTR DKNQIVVVDF NPDIIKQITA SGYNAVFGDI SDPEVLEELE FGRAKLIVVT
DPDVSDNIHL IRFAKGKNYK GPIIATAYWL HDAIRLYESG ADYVVVPETV GGKHLAKLLG
DHWDNLAAIK KAKSQYFEEL LSHKIF
//
