ID A0A1F5KHG1_9BACT Unreviewed; 308 AA.
AC A0A1F5KHG1;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=A3D25_03020 {ECO:0000313|EMBL:OGE40328.1};
OS Candidatus Daviesbacteria bacterium RIFCSPHIGHO2_02_FULL_43_12.
OC Bacteria; Candidatus Daviesbacteria.
OX NCBI_TaxID=1797776 {ECO:0000313|EMBL:OGE40328.1, ECO:0000313|Proteomes:UP000177328};
RN [1] {ECO:0000313|EMBL:OGE40328.1, ECO:0000313|Proteomes:UP000177328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGE40328.1}.
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DR EMBL; MFDD01000012; OGE40328.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5KHG1; -.
DR Proteomes; UP000177328; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251}.
FT DOMAIN 63..281
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 308 AA; 34017 MW; EC754EABAB73351C CRC64;
MSPHSRLGLG TLIALCLAIF LARLIHGQAI YTVFSDIPTQ TQSKALQIIV NNRLKDQKGD
FAIVIENIQT KEQYHFNSQK LFPSGSFYKL VLIASVYKEL AKGSLTKETI LSASKDYLTE
SFGAVDFGYE NFSGPITLSL QDALNRVAQV SDNFAAIMLT DKVRELTSNQ QEPLAQMAQD
LGLKDTHFGQ PETTALDTAH FFRLLSEGKV LSPAASQEII DLLASSQINN RIPSLLPQIE
STVGGQPKRV KVAHKTAELP GLRHDGGIVF LPNNPYIIVL MSKNVQFEDD TVELLANLSK
DVYDYFAK
//
