GenomeNet

Database: UniProt
Entry: A0A1F5LFM3_9EURO
LinkDB: A0A1F5LFM3_9EURO
Original site: A0A1F5LFM3_9EURO 
ID   A0A1F5LFM3_9EURO        Unreviewed;       876 AA.
AC   A0A1F5LFM3;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   31-JUL-2019, entry version 17.
DE   RecName: Full=Urease domain-containing protein {ECO:0000259|PROSITE:PS51368};
GN   ORFNames=PENARI_c012G08284 {ECO:0000313|EMBL:OGE51751.1};
OS   Penicillium arizonense.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=1835702 {ECO:0000313|EMBL:OGE51751.1, ECO:0000313|Proteomes:UP000177622};
RN   [1] {ECO:0000313|EMBL:OGE51751.1, ECO:0000313|Proteomes:UP000177622}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 141311 {ECO:0000313|EMBL:OGE51751.1,
RC   ECO:0000313|Proteomes:UP000177622};
RX   PubMed=27739446; DOI=10.1038/srep35112;
RA   Grijseels S., Nielsen J.C., Randelovic M., Nielsen J., Nielsen K.F.,
RA   Workman M., Frisvad J.C.;
RT   "Penicillium arizonense, a new, genome sequenced fungal species,
RT   reveals a high chemical diversity in secreted metabolites.";
RL   Sci. Rep. 6:35112-35112(2016).
CC   -!- COFACTOR:
CC       Name=Ni cation; Xref=ChEBI:CHEBI:25516;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001222-51};
CC       Note=Binds 2 nickel ions per subunit.
CC       {ECO:0000256|PIRSR:PIRSR001222-51};
CC   -!- PTM: Carbamylation allows a single lysine to coordinate two nickel
CC       ions. {ECO:0000256|PIRSR:PIRSR001222-50}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OGE51751.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; LXJU01000012; OGE51751.1; -; Genomic_DNA.
DR   OrthoDB; 183108at2759; -.
DR   Proteomes; UP000177622; Unassembled WGS sequence.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   GO; GO:0009039; F:urease activity; IEA:InterPro.
DR   GO; GO:0043419; P:urea catabolic process; IEA:InterPro.
DR   CDD; cd00375; Urease_alpha; 1.
DR   CDD; cd00407; Urease_beta; 1.
DR   CDD; cd00390; Urease_gamma; 1.
DR   Gene3D; 2.10.150.10; -; 1.
DR   Gene3D; 2.30.40.10; -; 1.
DR   Gene3D; 3.30.280.10; -; 1.
DR   HAMAP; MF_01953; Urease_alpha; 1.
DR   InterPro; IPR006680; Amidohydro-rel.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR008221; Urease.
DR   InterPro; IPR011612; Urease_alpha_N_dom.
DR   InterPro; IPR017950; Urease_AS.
DR   InterPro; IPR005848; Urease_asu.
DR   InterPro; IPR017951; Urease_asu_c.
DR   InterPro; IPR002019; Urease_beta.
DR   InterPro; IPR036461; Urease_betasu_sf.
DR   InterPro; IPR002026; Urease_gamma/gamma-beta_su.
DR   InterPro; IPR036463; Urease_gamma_sf.
DR   InterPro; IPR029754; Urease_Ni-bd.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   Pfam; PF00449; Urease_alpha; 1.
DR   Pfam; PF00699; Urease_beta; 1.
DR   Pfam; PF00547; Urease_gamma; 1.
DR   PIRSF; PIRSF001222; Urease; 1.
DR   PRINTS; PR01752; UREASE.
DR   SUPFAM; SSF51278; SSF51278; 1.
DR   SUPFAM; SSF51338; SSF51338; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
DR   SUPFAM; SSF54111; SSF54111; 1.
DR   TIGRFAMs; TIGR01792; urease_alph; 1.
DR   TIGRFAMs; TIGR00192; urease_beta; 1.
DR   TIGRFAMs; TIGR00193; urease_gam; 1.
DR   PROSITE; PS01120; UREASE_1; 1.
DR   PROSITE; PS00145; UREASE_2; 1.
DR   PROSITE; PS51368; UREASE_3; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000177622};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00700};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Nickel {ECO:0000256|PIRSR:PIRSR001222-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000177622}.
FT   DOMAIN      440    876       Urease. {ECO:0000259|PROSITE:PS51368}.
FT   ACT_SITE    631    631       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR611612-52, ECO:0000256|PROSITE-
FT                                ProRule:PRU00700}.
FT   METAL       445    445       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       447    447       Nickel 1; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       528    528       Nickel 1; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       528    528       Nickel 2; via carbamate group.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       557    557       Nickel 2; via pros nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       583    583       Nickel 2; via tele nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR001222-51}.
FT   METAL       671    671       Nickel 1. {ECO:0000256|PIRSR:PIRSR001222-
FT                                51}.
FT   BINDING     530    530       Substrate. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00700}.
FT   MOD_RES     528    528       N6-carboxylysine. {ECO:0000256|PIRSR:
FT                                PIRSR001222-50}.
SQ   SEQUENCE   876 AA;  94669 MW;  EE6701B84B79FCDF CRC64;
     MWPDNGAYYM KNPNGTVFAV ASDECQPYPA RQDPCSGSTA MQLVPKELDK LTIAHLGFLA
     QRRLARGVRL NHAEAVALIS SVLHELIRDG QYSVADLMSI GKTMLGRRHV LPSVVATLVE
     LQVEGTFISG TYLVTVHHPI SSNEGDLERA LYGSFLPVPA PEAFPDPDPE DFRPEKMPGA
     VIPAKHARVE LSSGRRRIRL KVMSKGDRPI QVGSHYHFIE TNPQLHFDRI QSYGFRLDIP
     AGTSIRFEPG DTKTVTLVEI GGNRVIRGGN WLANGPVDLN RAEEIVTKLQ TAGFAHVPEP
     QADSVLVSGF SMEREAYSRM FGPTTGDLVR LGLTDLWIKV ENDLTSYGDE CAFGGGKTLR
     EGMGQASGRG HAECVDTVIT NALIIDWTGI YKADIGIKDG LIAGIGKAGN PDVMDGVHPD
     LVVGSSTDVI AGENKIITAG GIDTHIHLIC PQQVEEALAS GITTFLGGGT GPSTGSNATT
     CTPGPNHLRQ MMQACDSLPI NIGITGKGND CGRKSIEEQI LAGAAGLKLH EDWGSTPAAI
     DKCLEVCDEY DVQCMIHTDT LNESGFVEQT IEAFKGRTIH TYHTEGAGGG HAPDIISVVE
     HPNVLPSSTN PTRPFTLNTL DEHLDMLMVC HHLSKNIPED VAFAESRIRA ETIAAEDVLH
     DLGAISMMSS DSQAMGRCGE VILRTWHTAH KNKTQRGPLG TDADTGADNF RVKRYISKYT
     INPALAQGMA HAIGSVEVGK VADLVMWKPS TFGTKPVSVL KSGMIAVAEM GDPNASIPTI
     EPMIMRPMFA VRVPETSIMF VSQASIDAGI VQSYGLKKRI MPVKNCRTVG KKDMKFNDTM
     PKMKVDPESY TVEADGMLCD AEPASELPLT QAYYIF
//
DBGET integrated database retrieval system