ID A0A1F5LQ69_9EURO Unreviewed; 1260 AA.
AC A0A1F5LQ69;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 08-NOV-2023, entry version 30.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PENARI_c004G04511 {ECO:0000313|EMBL:OGE55354.1};
OS Penicillium arizonense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1835702 {ECO:0000313|EMBL:OGE55354.1, ECO:0000313|Proteomes:UP000177622};
RN [1] {ECO:0000313|EMBL:OGE55354.1, ECO:0000313|Proteomes:UP000177622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 141311 {ECO:0000313|EMBL:OGE55354.1,
RC ECO:0000313|Proteomes:UP000177622};
RX PubMed=27739446; DOI=10.1038/srep35112;
RA Grijseels S., Nielsen J.C., Randelovic M., Nielsen J., Nielsen K.F.,
RA Workman M., Frisvad J.C.;
RT "Penicillium arizonense, a new, genome sequenced fungal species, reveals a
RT high chemical diversity in secreted metabolites.";
RL Sci. Rep. 6:35112-35112(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGE55354.1}.
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DR EMBL; LXJU01000004; OGE55354.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5LQ69; -.
DR STRING; 1835702.A0A1F5LQ69; -.
DR OrthoDB; 22721at2759; -.
DR Proteomes; UP000177622; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 1.
DR CDD; cd05137; RasGAP_CLA2_BUD2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000177622}.
FT DOMAIN 503..671
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 726..960
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1113..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..85
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1191..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1260 AA; 141533 MW; 1E8C2D705AF3C2F4 CRC64;
MEPDPNAFKR SSMQQALYSR PVERRASKKS SSRDRHGMVY PDSFRETTIR TVTPESHSPA
NHSPLSEPDP LSGGTSSPQS TLPSRPTEPE RRREFSKHSS RGGEEDTPPE GRSQRARSRT
TAAEEQRNET TPSSFKTRTR IGSINTASPS QPKVPEDPSS SIGFPSIQSR QYHSHSVPRQ
RSSKPVTGIA DSQDSFASPL SSSEATKILQ LMKTTCGRMH GILSFRTAST TSWTSGYCAI
NVATGSLIYQ AKGEPALAKT LIPDLRGCRV RTLFDPELQT TYLSVHTFTS GLGIQLRPHV
NETFDSWLAA LLCWQPIRPK GVQNKMTKPQ EVVIGDRRIP ERRRNSESAA QKDATIIKVG
KMLLWDKPSA SGAMPISGRR VSTYRQSRAL SSSWQKVSCT LQENGFFKLY TETDVSLLAC
VQLSQLSRCA IQQLNPSVLD DEFCIAIYPQ YAAHPVPDSN VRPIYLALES RVLFEVWFVL
LRAFTIPELY GPASKTEDPN KTPEADATVT PVLKDMFRIE RFLNLKIVEA KLFRAKEDTP
RSRKASRSHG HGQQTPTSKV SDYYTEVLLD GEIRGKTAVK YRTTNPFWRE DFVFSDLPPV
LSQASILVKT LNPTQKDWTL IAHGASNQDV NAVNAVNLLD EIEISANDAI FGRVDMRLEE
LDAGVDTEKW WPILDDQDQA VGEMFMRARM EETVVLMSDE YAPMSELLHS FTNGLTINMA
QVMSSELTHL AEMLLNIYQV SGSTVEWISA LVEDEIDGVH KESTTNRLRY TTRIHSNNSQ
ESGQEREVLV RDMGRTATVE ANLLFRGNSL LTKALDLHMR RLGKQYLDDT IAERLRDIDE
SDPECEVDPS RVPRHEDLER NWRNLTALTT SVWKSIAGSA SRCPPELRRI FRHVRACADD
RYGDFLRSVT YSSVSGFLFL RFFCPAILNP KLFGLLKDHP RPRAQRTLTL IAKALQGLAN
MTTFGNKEPW MEPMNKFLVG HRSDFKDFVD SICAIPADRP APIVTPSYTT PIQILGRLPP
TSREGFPSLP FLIDHARCFA NLIRVWLDVA PARLNDLGEL DVNLAKFHQT ALDLRARTEE
CLSRAEQAER PSGSLEIKWE ELVDSMERPV TFYDERSSQP STPAADPMMS GSAPAPSSHR
NSIGYFASRP SIPRRSTDHA PDADEDTPPS SSSATWDQSR IPFAIPRWSD ARDSTGSSKN
SSTYSLEYSD TSKVRRASVT KESSSKYRFF DFVPAPSRRK HKDRDQSQNN NSHEDLRNES
//
