ID A0A1F5LW72_9EURO Unreviewed; 687 AA.
AC A0A1F5LW72;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 28.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OGE57392.1};
GN ORFNames=PENARI_c002G06914 {ECO:0000313|EMBL:OGE57392.1};
OS Penicillium arizonense.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=1835702 {ECO:0000313|EMBL:OGE57392.1, ECO:0000313|Proteomes:UP000177622};
RN [1] {ECO:0000313|EMBL:OGE57392.1, ECO:0000313|Proteomes:UP000177622}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 141311 {ECO:0000313|EMBL:OGE57392.1,
RC ECO:0000313|Proteomes:UP000177622};
RX PubMed=27739446; DOI=10.1038/srep35112;
RA Grijseels S., Nielsen J.C., Randelovic M., Nielsen J., Nielsen K.F.,
RA Workman M., Frisvad J.C.;
RT "Penicillium arizonense, a new, genome sequenced fungal species, reveals a
RT high chemical diversity in secreted metabolites.";
RL Sci. Rep. 6:35112-35112(2016).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGE57392.1}.
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DR EMBL; LXJU01000002; OGE57392.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5LW72; -.
DR STRING; 1835702.A0A1F5LW72; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000177622; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF1; METHYLENETETRAHYDROFOLATE REDUCTASE 1; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000177622}.
SQ SEQUENCE 687 AA; 76520 MW; BF0FB1241A0B7072 CRC64;
MEKKITEKIA ALPPDANYFS LEFFPPKTRM GFANLSARLE RMAQALRPLF VTVTWGAGGS
TAARSLELAE VCQRQLQLTT VLHLTCTNMS RKLVDMALDE AKALGLRNIL ALRGDPPRSE
EYNMHGEDDS NKDFTFAVDL VKYIRKTHGD YFCVGVAAYP EGHPADAFQD IQDPARDIPY
LVEKTVAGAD FIMTQLTYDI DAYTKFEDML RNHESGAFKT IPIIPGLMPI HSYKILTRVT
KLSHVTIPPP ISRRMEELKH DDDAVKRAGV DIVSEIVGGI KDLPCPGPRG FHFYTLNLEK
TVSFILEQSD LIPPYSEMDD SAIEEGAPLD FPGRALGRSR ASSMHSQPHN RVIVDKLSVH
ESSQDSVHEA LADSVGMPMQ PNRSTTLQIS EGLGSLGREA TWDDFPNGRW GDARSPAFGE
IDGYGPSLHV TSAAARRLWG HPVDSSDMST LFRRHVSGEL HMVPWSEGGA EEGSGGLNAE
TELIRPELLK LIDGRGWWTL ASQPAVNGVK SDHHIFGWGP QREGFVFQKP FVEFFCSSND
YINILKPLFA QHGHNKLTWF ATNITGAFES SLPAQPADVE LDDLGSNPES VNAVTWGVFR
GKEIVTPTII EEVSFRAWGE EAFRIWDEWR RIYPRGSPTE TYLDTTKNDA WLVCVVGQQF
GAGTKRGSKE EEDEVKWMWR VLAGEDA
//