ID A0A1F5XF65_9BACT Unreviewed; 648 AA.
AC A0A1F5XF65;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=UvrABC system protein B {ECO:0000256|ARBA:ARBA00029504};
GN ORFNames=A3B19_00525 {ECO:0000313|EMBL:OGF86565.1};
OS Candidatus Giovannonibacteria bacterium RIFCSPLOWO2_01_FULL_46_32.
OC Bacteria; Candidatus Giovannonibacteria.
OX NCBI_TaxID=1798353 {ECO:0000313|EMBL:OGF86565.1, ECO:0000313|Proteomes:UP000177346};
RN [1] {ECO:0000313|EMBL:OGF86565.1, ECO:0000313|Proteomes:UP000177346}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC lesions. Interacts with UvrC in an incision complex.
CC {ECO:0000256|ARBA:ARBA00026033}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the UvrB family.
CC {ECO:0000256|ARBA:ARBA00008533}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGF86565.1}.
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DR EMBL; MFIF01000017; OGF86565.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F5XF65; -.
DR Proteomes; UP000177346; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd17916; DEXHc_UvrB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004807; UvrB.
DR InterPro; IPR041471; UvrB_inter.
DR InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR NCBIfam; TIGR00631; uvrb; 1.
DR PANTHER; PTHR24029; UVRABC SYSTEM PROTEIN B; 1.
DR PANTHER; PTHR24029:SF0; UVRABC SYSTEM PROTEIN B; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF12344; UvrB; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 24..158
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 426..588
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 616..648
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
SQ SEQUENCE 648 AA; 73881 MW; 504AE9E60A564ED1 CRC64;
MSFRLYAPYT PAGDQPQAIE KLARGLDAQK RYQTLLGVTG SGKTFTMAHV IAKTARPALI
LSHNKTLAAQ LYEEFKEFFP ESAVHYFVSY YDYYQPEAYL PNTDTYIEKD AKINQFIDEL
RHSATQAALT RRDCIIVASV SAIYGIGNPE EYLRFALTIH EKDALSQKTF SEKLAAMQYA
RNDIERSPGI WSKKGDTYIV VLPTGDRVLR VHFSGDEIEE IYEGGALSEP HFFRIRAVTI
FPAKHFVTPE ENLSGALAAI EQELKDRVRE LKKEKKVLEA ERLTRRTRYD INMLRETGYT
NGIENYSRPL SGRAPGEPPS TLIDYIPEEF ITFIDESHMT IPQIRGMYHG DRARKTTLVE
HGFRLPSALD NRPLTFSEFE KKVGQVVFVS ATPSEYERAR GNIVEQLVRP TGLLDPTLEI
RPAENQAKDV EKEIEKRALK KERSLIIALT KRMAEDIAEY LAGKNLKIAW IHSEVKTIER
YDILKSLRSG ESDALVGINL LREGIDVPEV SLICILDADK EGFLRNTTTF IQTIGRAARN
INGHVIFYAD RITDSMKNAI AETDRRRTYQ QEFNKKHGIA PSPIKKELRQ SLFANFKKSP
KEAIIDALKN DKRSRTELKK EIEMEMFEEA AALNFERAAE LRDILKGL
//
