ID A0A1F6B0I8_9BACT Unreviewed; 386 AA.
AC A0A1F6B0I8;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00012980};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
DE Flags: Fragment;
GN ORFNames=A2973_01025 {ECO:0000313|EMBL:OGG30445.1};
OS Candidatus Gottesmanbacteria bacterium RIFCSPLOWO2_01_FULL_49_10.
OC Bacteria; Candidatus Gottesmanbacteria.
OX NCBI_TaxID=1798396 {ECO:0000313|EMBL:OGG30445.1, ECO:0000313|Proteomes:UP000176409};
RN [1] {ECO:0000313|EMBL:OGG30445.1, ECO:0000313|Proteomes:UP000176409}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway.
CC {ECO:0000256|ARBA:ARBA00004725}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGG30445.1}.
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DR EMBL; MFJZ01000022; OGG30445.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6B0I8; -.
DR STRING; 1798396.A2973_01025; -.
DR Proteomes; UP000176409; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR CDD; cd06223; PRTases_typeI; 1.
DR CDD; cd01672; TMPK; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018094; Thymidylate_kinase.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}.
FT DOMAIN 12..187
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
FT DOMAIN 251..344
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
FT NON_TER 386
FT /evidence="ECO:0000313|EMBL:OGG30445.1"
SQ SEQUENCE 386 AA; 43437 MW; 57AAD5659F648C04 CRC64;
MQTIETQQSY AFEGLDGSGK TTIIAMLVED LEALGLRVAV NSSPGKTWTG HVLKECMAHI
EPNKKNELFT YDIRRTERTI PHTVNMVLWD RHLDSVVVSN GDDANEEVAK YAEGIVRPHI
VIYLDISPDI SWERESKNTD HPLDTDWLRA KHRRYHELMI DDATPDARSG GKFVIFDASK
PLEKVYASVR DYFLKEAGPL IEKNKAMYEL LLETPGIIQF LLDNPFEVKP DVYLPMFVNL
KNTWSIPDVR NMIVQNLAQL VDEDIDWIIG LESGGSYYAV ALANMLGKPV SLLRKNVKEH
GNNNYLVGEA PPVGSKVVLV DDVYATGQSA SRALEQLALN RCRCSLVTIF SYSNDKEIQD
RLGISGTALT YFKGILHRAK EKGLLN
//
