ID A0A1F6BDF6_9BACT Unreviewed; 313 AA.
AC A0A1F6BDF6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN ORFNames=A2363_01775 {ECO:0000313|EMBL:OGG34930.1};
OS Candidatus Gottesmanbacteria bacterium RIFOXYB1_FULL_47_11.
OC Bacteria; Candidatus Gottesmanbacteria.
OX NCBI_TaxID=1798401 {ECO:0000313|EMBL:OGG34930.1, ECO:0000313|Proteomes:UP000176186};
RN [1] {ECO:0000313|EMBL:OGG34930.1, ECO:0000313|Proteomes:UP000176186}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGG34930.1}.
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DR EMBL; MFKE01000019; OGG34930.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6BDF6; -.
DR STRING; 1798401.A2363_01775; -.
DR Proteomes; UP000176186; Unassembled WGS sequence.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:InterPro.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251}.
FT DOMAIN 79..286
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 313 AA; 34704 MW; 095423663F7BD1E9 CRC64;
MKSVRILLIS GVALVGLYLL LNQLVKLERA NSHVISPLTD ATVTTSTVIP PVKDRSQANS
ERLKDVVDGA LEGATGSYGI YIKNLKTGES YVSGEHNVFD SASLYKLWVM AVVYQKIQDE
QFTEDQVLRE DVFVLNQKFD IDPELAEKTE GVITFSVREA LRQMITVSDN YAALLLTEKI
GLSSVATFLK ENDLTESAVG TTGGPPTSTP YDIERFLEKL YREDVANPKY TAEMIDLLKN
QKLNNGIPKY LPDASSVANK TGEIDRFKHD AGIIYTDNGD YSIVVMSESA YPPGAQERIA
RVSKAVFDYF THK
//
