ID A0A1F6BWA2_9BACT Unreviewed; 1386 AA.
AC A0A1F6BWA2;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN ORFNames=A2118_02200 {ECO:0000313|EMBL:OGG41200.1};
OS Candidatus Kaiserbacteria bacterium GWA2_50_9.
OC Bacteria; Candidatus Kaiserbacteria.
OX NCBI_TaxID=1798474 {ECO:0000313|EMBL:OGG41200.1, ECO:0000313|Proteomes:UP000179014};
RN [1] {ECO:0000313|EMBL:OGG41200.1, ECO:0000313|Proteomes:UP000179014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGG41200.1}.
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DR EMBL; MFKN01000006; OGG41200.1; -; Genomic_DNA.
DR STRING; 1798474.A2118_02200; -.
DR Proteomes; UP000179014; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR CDD; cd07484; Peptidases_S8_Thermitase_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR027618; Beta_prop_Msarc.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR034084; Thermitase-like_dom.
DR NCBIfam; TIGR04275; beta_prop_Msarc; 4.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF05345; He_PIG; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49313; Cadherin-like; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR SUPFAM; SSF69304; Tricorn protease N-terminal domain; 2.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1185..1286
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1297..1386
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1281..1303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 321
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 385
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 561
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1386 AA; 145542 MW; 543055097AAEB764 CRC64;
MHSLKGQASL EYLLLLGAVA LVTVVAITMV LGISGAQQES ILSTISRIPV VPTGTIDSGG
AEEPAAITFS GESGELSVAG QYFPSTKTLR AVFNRPVSGE SFKLTVFSEP LALESTDCQS
FDGTRFDCFL KPGQFIEKGT HYLEVEAAAL SNPAEIVKLK SGNFSVSEED VQASKAADDL
PEFAAGEIIV KFKGKVNERA KADTAAGATK VETDKESVNA LLNKYKAKEI RGVITSGKAL
QKKPDFANIK KIEIDGDVKA AAAEFAQDPN VEYAEPNFVQ FSSFNPNDQK FSEQWALQKI
QAQQGWDTLY GSPNTVIAII DTGVDYGHED LAANMLANCS GGCPQGAGYD FVNTDTTYWT
SNGFTLYSSE DYITPDNSPS DFVGHGTHVA GIAAGVTNNT KGIAGVCPEC SIMPVKAGFG
VQHPYYCPNG CGVLELDAIS NALVYATDNS ADVINMSFGG SYSSLQEDAI NYAFNAGVVL
VASAGNSGNS TPNYPAALAN VISVSATTPS DLLAPYSSFG NSVDVAAPGG DGTSANGILN
TLPKTGMLND ASGYGKLNGT SMASPHVAGL AGLIISAKPT LSNIGVGNII RNSADDLGTA
GFDSYYGYGR INLLKASYAF DSTNQPPLVA KPFVRMVAVG PGKAGNLGRL LEFKVGIQDP
DDPSTPQGQL VYSGTGMPPS ATLDASTGIF SWKPAMNELG TYQITFTAVE AGGQYSASQN
ITISTLFKPE TRVTPFSGDQ QSPDVSGGKV VWSDSRNDAS DVYMYDISAG GDPATNSQPI
AVDSQFQWFP AIDVSKIVWN DYRSTVQGVT ASDVFMKDIS TSNSAVQLTP SSSFQGDPDI
SGNTVVWTDY RNDSSGTYSN GDIYMKSLPN GNEMPVTTNS AHQTKPKIDG STIVWADFRA
GNGYWDIYTL YNGKETRVSS FSTNWGNANP HIYGSRIVWQ GFSGGAYNIY MKDLAGGVET
KITNDFYGQD TPAIFEDKVV WRDSRAGGGN GDIYLYDLLT GVETQLNVDP SNQLGPEIDH
ENVVWTDERN GGGNRDVYMT QMYFAPEIVS IQQNGNSITI DGYNFGYAQA ADSSVQFSSG
GTVTGTATIS SWSNTKIVAS APSNSNDTIT LNTKGGKSNP ATIGGGPAPV CGNSACEAGE
DATSCPADCG VSGPVCGNNV CEAGEDSLNC ALDCPAPPSN IKPAAPTNLS AIADSAALQI
GLYWTDNSQA GDPDNETSFI IERGVKSKRN ISFQQIATAG PDEVSFTDTT DTGLKASTAY
YYRVKARNAY GDSAYTNNAS ATTPSGGGGG SSNVPAAPSG LSGTALSSSE IELSWTDNSG
NEDGFSIERS VKIQGQTTVA NFTVGSGTES FNDSGLQANT SYKYAVKAFN QYGSSAEASV
TVKTSR
//
