ID A0A1F6DVH0_9BACT Unreviewed; 711 AA.
AC A0A1F6DVH0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=A3C94_02130 {ECO:0000313|EMBL:OGG65022.1};
OS Candidatus Kaiserbacteria bacterium RIFCSPHIGHO2_02_FULL_55_17.
OC Bacteria; Candidatus Kaiserbacteria.
OX NCBI_TaxID=1798496 {ECO:0000313|EMBL:OGG65022.1, ECO:0000313|Proteomes:UP000177232};
RN [1] {ECO:0000313|EMBL:OGG65022.1, ECO:0000313|Proteomes:UP000177232}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGG65022.1}.
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DR EMBL; MFLJ01000003; OGG65022.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6DVH0; -.
DR STRING; 1798496.A3C94_02130; -.
DR Proteomes; UP000177232; Unassembled WGS sequence.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670}.
FT DOMAIN 56..228
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 318..573
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 711 AA; 77066 MW; 8A45FC1267514BC0 CRC64;
MFLAFILALF GLGFFIGGGL LVVVALTPVP DISSFSSRQV DQSTKIYDRT GQVLLYDYNR
DARRSVVPLA DISPHAISAT IAIEDSSFYA HGGIRLTSIL RAILADAVGG SLSQGGSTIT
QQVVKNELLT SRKSIIRKIH EWVLAIKLEQ VYSKEQILET YLNSIPYGGT LYGIEAASES
YFGIPAKDLS LAQAAYLASM IQAPTYYSPY GTHRAALDAR KDTILERMRT LGFISDAASV
TAKEEGVSFS PTGRNSIAAP HFVFYILNLL EERYGSQALI SGLKVTTTLD ADLETKAEAI
VNQYALENEK KFKASNASLI ALDPSTGQIL AMVGSRSFFD TTIDGQYNAS LASRQPGSTM
KPFIYSLALM KGYTRNTVVF DTPTQFSTAC NPSDIYNNTP PCYAPSDYDN TFRGPMTFET
ALAQSINIPA LKVLYLVGIQ QAITLAKSFG LTTLGDPNQY GLTLVLGGGE VRLLDLVGAY
AVFANEGVKN TPTGILEVAD AQGTLLESYA PQSSQVVPAN IARDMSAMLS DAPARLPEYP
LNSPLSFSGY EVAVKTGTTD DTRDAWVIGY TPSLALGVWA GNNDNSPMVK SIAGFIAAPM
WHEAMAYALS KYPKTYFGEP SPILSTVPPM LRGDWYIPDA QGNIVPHDLL YWTDKHNPQG
PPPINPARDP QFAYWEYGLS VWYESHPNLF QGGIMLPVPL STATTSIVMA P
//
