ID A0A1F6LGX6_9BACT Unreviewed; 672 AA.
AC A0A1F6LGX6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=A2725_02655 {ECO:0000313|EMBL:OGH58579.1};
OS Candidatus Magasanikbacteria bacterium RIFCSPHIGHO2_01_FULL_33_34.
OC Bacteria; Candidatus Magasanikbacteria.
OX NCBI_TaxID=1798671 {ECO:0000313|EMBL:OGH58579.1, ECO:0000313|Proteomes:UP000177067};
RN [1] {ECO:0000313|EMBL:OGH58579.1, ECO:0000313|Proteomes:UP000177067}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGH58579.1}.
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DR EMBL; MFPS01000009; OGH58579.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6LGX6; -.
DR Proteomes; UP000177067; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF3; ATP-DEPENDENT HELICASE_DEOXYRIBONUCLEASE SUBUNIT B; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 6..290
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 291..555
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 672 AA; 76914 MW; AC1930E89BFF5B82 CRC64;
MIDYKNELNE EQYRVVTEGD GPCLVLAGAG SGKTRAITYR VAYLLEHGVS PQNILLVTFT
NKAANEMMFR VKSLLGDELK LMWAGTFHHI GYRILRQYSA LIGYKNNFNI LDTQDSLDLF
KLCLKQEGMG RKEKRYPSAK VIQSIVSYAR NAELSVEEVL NQKYPNWSDI ADKVSLIAHE
YSKRKLESNT MDFDDLLVNT YLLLCRSQSV QKKLSEQFKY VLVDEYQDTN KIQASIISLL
SSYHKNILVV GDDAQSIYSF RAADIENILG FENKYPNARI FKLETNYRST PDILNVANVV
IENNLNQYKK DLKSVLENFT KPEAHAFADS QEEANFIVGR ILELYDEGIE FNKMAVLFRA
AYHSQALEVE LTRRDIPYEF RGGVRFFERS HIKDVLAYLK IYNNIQDEIA WSRVLNMQVG
IGPASAQAII GKVKNIKDKS EINSVTDDLS PRAKIGWGDF VQIWNSMDRE VVKVPSALIQ
AVIQSKYKEY LEQEYPDARE RMQDLEQLAM FADKQLDLDK FLAEASLQEG YGSKNRQTSD
NEPKLVLSTI HQAKGLEWEG VFIMSLNSGQ FPSDRSMKEM NGLEEERRLF YVAITRAKKY
LYFSYSLSGG FGSFLQGPSM FLDEIGDQLI EGNTFKSGTV FDDDKDDIIY VTDDEPFTNQ
PRTSFLSSID EL
//
