ID A0A1F6N2N6_9BACT Unreviewed; 1606 AA.
AC A0A1F6N2N6;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 13-SEP-2023, entry version 20.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=A2983_03665 {ECO:0000313|EMBL:OGH78144.1};
OS Candidatus Magasanikbacteria bacterium RIFCSPLOWO2_01_FULL_40_15.
OC Bacteria; Candidatus Magasanikbacteria.
OX NCBI_TaxID=1798686 {ECO:0000313|EMBL:OGH78144.1, ECO:0000313|Proteomes:UP000177040};
RN [1] {ECO:0000313|EMBL:OGH78144.1, ECO:0000313|Proteomes:UP000177040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGH78144.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MFQH01000017; OGH78144.1; -; Genomic_DNA.
DR Proteomes; UP000177040; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd00081; Hint; 2.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR01443; intein_Cterm; 1.
DR NCBIfam; TIGR01445; intein_Nterm; 1.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF14890; Intein_splicing; 1.
DR Pfam; PF14528; LAGLIDADG_3; 1.
DR Pfam; PF02811; PHP; 1.
DR PRINTS; PR00379; INTEIN.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
DR PROSITE; PS50818; INTEIN_C_TER; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
PE 4: Predicted;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protein splicing {ECO:0000256|ARBA:ARBA00023000};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 870..1010
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 1166..1188
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
SQ SEQUENCE 1606 AA; 180668 MW; 7C4F687874C2E61B CRC64;
MTDFVHLHVH SHYSLLNGLT KIKALVKAAK ARGFSALALT DYGSMYGAIE FYQACLAEGI
KPIIGFEAYI APRSRLDKDP AHDSTLYHLI LLAENYNGYK NLMKLSSFGH LEGFFNGKPR
IDKELLRKYH ENIIVLSGPI EGEIPTLIKN GEIAKAKAVA REYQEMFSST SLTASGSDYF
YLELEDHPAI SGQIEVNTKL IELGKELGIP LVVTRDVHYL NPDDDEAQDI LRCIAEGWRV
DQPNRIDYRG VDRSFATGDD IAARFRHVPE AIANTIKIAE RVNIQIELNK WHFAPVELPP
GKTADDVLAE EAHNRVTIYF KEKTAELTER LNYELEIIKT KKYSPYFLCV ADFVRYAKDH
GIVESTRGSA AGSLVSYVMG ITTVDPMRFN LPFERFLNPF RPSPPDVDTD FADDRRDEMI
EYVTKKYGAD KVAQIITFGT MAARASVRDV GRALGFAYSF CDQVAKLIPQ GAQGFPMTIG
RALTEEPDLK KLYEQNADVK RLLDLARKVE GCARHTSIHA AGVVIAPTAL MDFSPVQYET
GGTRITTQYE MKSVEAAGVL KNDFLGIRNL AILGNAVEFV KKTTGQEIDI YNLPLDDAKV
YEMLARGETM GVFQLGGSGM TRWLKELKPN RIEDIMAMVA LYRPGPMESI PEYIRRKYNP
EAVKFFDSRL EKILGASYGL LVYQDDVMLT AIALAGYDWM EADKFRKAMG KKIPEEMAKQ
KEQFYKGCQE IGKVKKDIVD EIWHAIEPFA AYGFNKCLVG ETEIVDAATG AIRTIKEMYE
QKSRMSVLSL SGYKKLIKRK IIDIYKNGKK PVWEITIRSG RKITATGNHP FLKFGGWFNL
EKLCVGDLIA VPRKIDYRPS ADLDSKKLKV LGYLLSEGNL CHPYGVYFYS SVEVEIQDFI
TAVKSFSNSN VTINRSKSAA AVYVGQINPK FRNNLMLWLK ELGLYNKKAT EKFIPEFIFK
LSPEKIAVLV GSMWQGDGCV HDDKNGQIYY ATSSEKLAQQ MQHLLLRLDI LSTIYTKKFT
YRNGLKIGYT INISRYNNLA NFAHTVGQHL LPNKKIILNN IIKKNKILNG TLHTGVARGS
KDVVPAQILE LIRKELGQKG ITIKTISQEL KIAERLFYQD TKRKGYLRET VGKIGIYLKS
TKLLQEARSE LYWDEIVSIK SRGMQETYDL TVLGEHNFVA NDFVVHNSHA ASYGIVAYQT
AYLKAHYPVQ FMTAILQAEA SDLEKVAAIV YECGRMGIEV LPPDINESFK SFAMVSKPGL
LDPAQGKPGR IRFGLNAIKN VGEHICEVIY RERKEHGAYQ SLENFLERIT DKDLNKKSLE
SLVVAGALDC FGFDRNVLFA NSENMLFFYR QARDRELTKQ DSLFAATDIS LDSKVMLKPA
PNATMEQKLT WEKDLLGLYL SAHPLHPFVD ALKGVVIPLA EVESAPRDSW VVCFGVVESI
KKKITKKGDM MLFVVIQDLS ATMELLVFPK TYARTKDLWL ERALICIVGK TPREEGENKI
FVENAYELRR ETISDLARQL ALSVGQKLNS DVGAVPEKYL RIILSADELQ TSAEPIKTIL
ATHPGDTTVY LQVGTGTIKV GTKVNASEEL LSELIKILGD AKVEMF
//