ID A0A1F6PJC8_9BACT Unreviewed; 739 AA.
AC A0A1F6PJC8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE RecName: Full=HD/PDEase domain-containing protein {ECO:0000259|SMART:SM00471};
GN ORFNames=A2039_04260 {ECO:0000313|EMBL:OGH96261.1};
OS Candidatus Melainabacteria bacterium GWA2_34_9.
OC Bacteria; Candidatus Melainabacteria.
OX NCBI_TaxID=1801604 {ECO:0000313|EMBL:OGH96261.1, ECO:0000313|Proteomes:UP000198266};
RN [1] {ECO:0000313|EMBL:OGH96261.1, ECO:0000313|Proteomes:UP000198266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGH96261.1}.
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DR EMBL; MFRJ01000096; OGH96261.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6PJC8; -.
DR STRING; 1801604.A2039_04260; -.
DR Proteomes; UP000198266; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF07697; 7TMR-HDED; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 485..644
FT /note="HD/PDEase"
FT /evidence="ECO:0000259|SMART:SM00471"
SQ SEQUENCE 739 AA; 82855 MW; 6A970833BE9228F5 CRC64;
MHISKHSKLV KKILQLITSE KFSAVLILLV SVIVLTGLLA SRYYLFQNIV DNGMSKVDVI
ASKNIQVEDP DKIEMEKQEE AAKIKPVLRP SQDGIDEYIR KNLGELLNSI KEVREKSASD
SAKRTEIKEL LEIAEDNYFI NNSIDYLFKS SESGYARIAS ESLNSLNGIL DEGLSDSDFI
AKRSDILNNN IRISLPKTQK RAIFLVLNKI LEPNMTEDKI ATELERQKAI NQVKPIYSNF
KKGDIIVSVG DKITRVQKAA LKKIGYNVAQ IDFLGLFGIF SLVSLCIFTL AYYLINFDSK
FLKPCYLCLI ALLTGTVTLF AVFLPPDIPV YVIPIPAIAM LLTIFTSSRI SMLVTILIII
MLGVALQYQT ADIFVFLLGA LIAIFTSNSV NYYRRMDIVR SGFDVGLIQT FVILSIFLLQ
NGTDNIDITA LVKSIFLGFA NGLGSGIIAL GSLPLIESAF KIITPYGLAE LADHNQILLR
RLQFEAPGTY HHSLMVSNLC EAAAEAIDGN PVLARVGAFY HDIGKLKRPL FFIENQSYFG
IENPHEKLNP RLSKMVITAH PKDGLELAKE YGLPPVILQF IIQHHGDGIA SYFYMQALEQ
EGAENISEEQ FRYNNPKPST KEIAILMLAD AVESAVRSIK TPSQEMIEDI VENIIKERLY
DGQLSESPLT QKDLKVVAGV FKRVLRGMQH HRIKYHQNVL EELNQKTATT NIKQIQQQLE
AEVLPEIPPE EQPKENSQQ
//
