ID A0A1F6PVI0_9BACT Unreviewed; 488 AA.
AC A0A1F6PVI0;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN ORFNames=A2Y25_00365 {ECO:0000313|EMBL:OGI00186.1};
OS Candidatus Melainabacteria bacterium GWF2_37_15.
OC Bacteria; Candidatus Melainabacteria.
OX NCBI_TaxID=1801606 {ECO:0000313|EMBL:OGI00186.1, ECO:0000313|Proteomes:UP000178584};
RN [1] {ECO:0000313|EMBL:OGI00186.1, ECO:0000313|Proteomes:UP000178584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGI00186.1}.
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DR EMBL; MFRL01000094; OGI00186.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6PVI0; -.
DR STRING; 1801606.A2Y25_00365; -.
DR Proteomes; UP000178584; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR025274; DUF4070.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034530; HpnP-like.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF3; HYPOTHETICAL METHYLTRANSFERASE; 1.
DR Pfam; PF13282; DUF4070; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDF00303; hopanoid_C2-methyltransferase; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT DOMAIN 161..390
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 488 AA; 56247 MW; D6E4D791D835462E CRC64;
MRILMVYPEC PDTFWSLKHV VTLLGKKATL PPLGLMTVSS LLPKEFEKKL IDLNTTKLTD
EDILWADFVF ISAMIVQKSS AEEVIARCKK LGRKTVAGGP LFTSLHEQFE DVDCFTLNEG
EITIPMFLKD LENGELKRVY KTDIKPELGI SPVPDFSLIN HNEYYVMPVQ TSRGCPFDCD
FCDIVNLNGR IPRLKSPEQV IKELETIQKL GWNKSIFFVD DNFLGNKQKT KELLKAIIDW
RKKVDFKPLF YTEISINASD DDELLELMRQ AGFFMVFVGI ETPSTEGLQE CGKMQNQNRN
LVESIRKFYK YGMEVTGGFI VGFDSDDETI FQRQLDFIQE AGVTKAMIDI LQALPGTKLY
KRLEAEGRLM IQDSSGVCQD STTNFISKMD AKILSKGHKE LLKKAYSPKY YFERVDNFLK
FYEPTRKIPL RKRIIPSLLK IYFVLKYLKK GRMEFGLFMF KTLLTRINCF PAALDQSVLY
IHFSKVFN
//
