ID A0A1F6RDK3_9BACT Unreviewed; 519 AA.
AC A0A1F6RDK3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=A3B68_03440 {ECO:0000313|EMBL:OGI18708.1};
OS Candidatus Melainabacteria bacterium RIFCSPHIGHO2_02_FULL_34_12.
OC Bacteria; Candidatus Melainabacteria.
OX NCBI_TaxID=1801607 {ECO:0000313|EMBL:OGI18708.1, ECO:0000313|Proteomes:UP000198265};
RN [1] {ECO:0000313|EMBL:OGI18708.1, ECO:0000313|Proteomes:UP000198265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGI18708.1}.
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DR EMBL; MFRM01000021; OGI18708.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6RDK3; -.
DR STRING; 1801607.A3B68_03440; -.
DR Proteomes; UP000198265; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:OGI18708.1};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:OGI18708.1}.
FT DOMAIN 10..225
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 278..500
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 519 AA; 58393 MW; 248AB749303A20F4 CRC64;
MKDLAEKPIV YITGAGPGDP DLLTLKAKEI IEKADIIAYD NLVSKEILDL SAFLNPKVKL
IYVGKVGGEH DKSINQEQIN NLLFELTKDY KIICRLKGGD PNIFGRGGEE AIFLKENNIN
FEFIPGVSSI TAVPAYAGIP LTHRDCTSSF TVITAHEDPS NPENTINWES FDALKSTLVL
LMGIKNLPKI AEKLISLGRS KETPVAIIYW GTTHQQKTII TKLTNVIEDI AKNEVKAPSV
IVIGEVVNYR EILNWFETKS LFGKKVLITR SKEQSFSFVS KLLKSGVKPV LCPIVSYEPV
EKEVFNKNII NNLSGFDWVF FNSQNAVKFF FEILNKNCYD SRALSKCQIA AVGYKTKSEL
EKYNIKADFI PKRFSFEALI NELTEIEKLQ NKKILLPTQA GARHGMPQQD ITEWPIYTAN
FIRNLDTETI NKIQEGMDIL TFFSSNTVSH FAKLIEQHNL NNHIKNSKIA VIGDETAKIT
KELFSKVDII AEPFTEDGLI KSMERYFKCN VIPAKAGIQ
//
