ID A0A1F6RSY3_9BACT Unreviewed; 340 AA.
AC A0A1F6RSY3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:OGI23660.1};
GN ORFNames=A2255_03135 {ECO:0000313|EMBL:OGI23660.1};
OS Candidatus Melainabacteria bacterium RIFOXYA2_FULL_32_9.
OC Bacteria; Candidatus Melainabacteria.
OX NCBI_TaxID=1801611 {ECO:0000313|EMBL:OGI23660.1, ECO:0000313|Proteomes:UP000198209};
RN [1] {ECO:0000313|EMBL:OGI23660.1, ECO:0000313|Proteomes:UP000198209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGI23660.1}.
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DR EMBL; MFRQ01000002; OGI23660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6RSY3; -.
DR STRING; 1801611.A2255_03135; -.
DR Proteomes; UP000198209; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
FT DOMAIN 3..327
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 340 AA; 36832 MW; C101C7D374704B84 CRC64;
MYNITLIPGD GIGPEITEAA IKVIESTGIK INWEVVNAGS DFIETEGTPL PDKVLESIKK
NKVALKGPIT TPIGTGFRSV NVTLRKELDL FACVRPAKTI KGIKSKFDNI DLVVFRENTE
DLYAGIERQI DENTAESIKL ITRGASEKIA KAAFEYAVKE NRKKVTAITK ANICKLSDGL
FLEAAKKVAK DYPQIQYEEL LIDNMCMQLV QYPELYDVLL LPNLYGDIIS DLTAGLIGGL
GIAPGANYGT DLAIFEPVHG SSPGLKGLNK ANPTALILSA AMMLRHLGEV KAAKNIYNAV
AKVIQKNETV TFDLGGHAST MEMAQAIIAE MQNNSVSCKS
//
