ID A0A1F6V975_9BACT Unreviewed; 760 AA.
AC A0A1F6V975;
DT 15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=UvrABC system protein B {ECO:0000256|ARBA:ARBA00029504, ECO:0000256|RuleBase:RU003587};
GN ORFNames=A2647_03250 {ECO:0000313|EMBL:OGI66162.1};
OS Candidatus Nomurabacteria bacterium RIFCSPHIGHO2_01_FULL_40_24b.
OC Bacteria; Candidatus Nomurabacteria.
OX NCBI_TaxID=1801739 {ECO:0000313|EMBL:OGI66162.1, ECO:0000313|Proteomes:UP000177370};
RN [1] {ECO:0000313|EMBL:OGI66162.1, ECO:0000313|Proteomes:UP000177370}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=27774985; DOI=10.1038/ncomms13219;
RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA Williams K.H., Hubbard S.S., Banfield J.F.;
RT "Thousands of microbial genomes shed light on interconnected biogeochemical
RT processes in an aquifer system.";
RL Nat. Commun. 7:13219-13219(2016).
CC -!- SUBUNIT: Forms a heterotetramer with UvrA during the search for
CC lesions. Interacts with UvrC in an incision complex.
CC {ECO:0000256|ARBA:ARBA00026033, ECO:0000256|RuleBase:RU003587}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU003587}.
CC -!- SIMILARITY: Belongs to the UvrB family. {ECO:0000256|ARBA:ARBA00008533,
CC ECO:0000256|RuleBase:RU003587}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OGI66162.1}.
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DR EMBL; MFTP01000003; OGI66162.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1F6V975; -.
DR Proteomes; UP000177370; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR CDD; cd17916; DEXHc_UvrB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004807; UvrB.
DR InterPro; IPR041471; UvrB_inter.
DR InterPro; IPR024759; UvrB_YAD/RRR_dom.
DR PANTHER; PTHR24029; UVRABC SYSTEM PROTEIN B; 1.
DR PANTHER; PTHR24029:SF0; UVRABC SYSTEM PROTEIN B; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF12344; UvrB; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50151; UVR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003587};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769,
KW ECO:0000256|RuleBase:RU003587};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003587};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881,
KW ECO:0000256|RuleBase:RU003587};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW SOS response {ECO:0000256|RuleBase:RU003587}.
FT DOMAIN 27..166
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 484..656
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 711..746
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 449..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 257..284
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 760 AA; 86028 MW; 7334C3BE0526A6A4 CRC64;
MTQGIFKLHS PFKPAGDQPV AILKLLDGLE KGMQKQTLLG ATGTGKTFTM ANVIVEYNKP
TLVIAHNKTL AAQLAQEFRE FFPDSAVHYF VSYYDYYQPE AYMPTTDTYI EKDAQINKEI
DRLRHASTQA LLTRRDVIIV ASVSCIYGLG SPEEYEKVNL KIKLGMKMER LTLMKRLIEI
HFERTNADLT PGTFRSIGSW VEFMPVSETI MYQIEIDDGA VSKITKIDPI SSQIIKEEKD
VFIFPAKHFI TEDTKKNKAL IEIKKELALQ LKKFQKEGKL LEAERIKRRT NYDLAMIKEV
GYCSGIENYS RHLSGKQKGE PPETLLSYFP HTGDGEPDFL TIIDESHVTL PQLEGMYAGD
ASRKKTLVEY GFRLPSAKDN RPLKYEEFQK RIGPVVYTSA TPGKYEIEES KKECEQTCPA
RSTLSCGVVE QIIRPTGLVD PETIVRPVSA NSPLEEYPKG EVDEFSTPSR KRSTPQEGNK
YPGQIQDFIS EAEKTIKKGF RVLATTLTKK MAEDLSLYLK DLPAQAGKKI KSEYLHSDIK
TLERIQILSK FRKGDFDVLV GVNLLREGLD LPEVALIGIL DADKEGFLRS ETSLIQTIGR
AARNSEGKVI LYADVITGSM NKALAETARR RDIQLTYNKK HGITPKTIIK KIKDITEEFE
SEHGKAVNAE LKLDVEIFRR AYKKELTRPL KPKGLGESHL SDQEIEALTY EKIIKIKEKE
MNRAVKELDF ETAAILRDEI RVLSQKTVYG TGNKTKNVVP
//
